Rv2486

Tuberculist information
Gene nameechA14
Protein functionProbable enoyl-CoA hydratase EchA14 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2794.35
Molecular mass(da)26280.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 256
	  		  	1    MAQYDPVLLSVDKHVALITVNDPDRRNAVTDEMSAQLRAAIQRAEGDPDVHAVVVTGAGK   60
			  	61   AFCAGADLSALGAGVGDPAEPRLLRLYDGFMAVSSCNLPTIAAVNGAAVGAGLNLALAAD  120
			  	121  VRIAGPAALFDARFQKLGLHPGGGATWMLQRAVGPQVARAALLFGMCFDAESAVRHGLAL  180
			  	181  MVADDPVTAALELAAGPAAAPREVVLASKATMRATASPGSLDLEQHELAKRLELGPQAKS  240
			  	241  VQSPEFAARLAAAQHR

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 8 to 247  |  Coverage: 93% ECH Range: 2 to 256  |  Coverage: 99% 1 Range: 1 to 256  |  Coverage: 99% 1
Number of amino acids : 256
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003788-247
Mtb Structural Proteome models
Model Number1
Model nameRv2486
Template1MJ3    APDBCREDO
Template coverage31_282
Template Identity(%)29.2
Model coverage(%)99.2
Normalized DOPE score0.073

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore37.47
Residue begin1
Residue end256
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2486Gene nameConfidence Score
Rv0468fadB20.944
Rv0468fadB20.944
Rv0228Rv02280.92
Rv0215cfadE30.917
Rv0215cfadE30.917
Rv0215cfadE30.917
Rv1715fadB30.916
Rv1715fadB30.916
Rv1346mbtN0.911
Rv1346mbtN0.911
Rv1346mbtN0.911
Rv0852fadD160.911
Rv2502caccD10.909
Rv3761cfadE360.906
Rv0860fadB0.905
Rv0860fadB0.905
Rv0860fadB0.905
Rv0244cfadE50.904
Rv0244cfadE50.904
Rv0244cfadE50.904
Rv0244cfadE50.904
Rv0244cfadE50.904
Rv1467cfadE150.903
Rv1467cfadE150.903
Rv0400cfadE70.903
Rv1467cfadE150.903
Rv0400cfadE70.903
Rv1467cfadE150.903
Rv0400cfadE70.903
Rv1467cfadE150.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
crotonyl-CoAPubChem0.904835.608
C05268PubChem0.9881.677
3-hydroxybutyryl-CoAPubChem0.9853.623
C04405PubChem0.9867.65
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
C16468PubChem0.9875.672
AR-1A9122PubChem0.9787.566
c0887PubChem0.9935.767
flavin adenine dinucleotidePubChem0.9785.55
3-hydroxypropionyl-CoAPubChem0.9839.597
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
C11945PubChem0.9917.752
C05262PubChem0.9965.836
2-methylbutyryl-CoAPubChem0.9851.651
C01144PubChem0.9853.623
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
protiumPubChem0.92.01576
2-methylacetoacetyl-coenzyme APubChem0.9865.634
C05266PubChem0.9909.73
3-methylcrotonyl-CoAPubChem0.9849.635
methacrylyl-CoAPubChem0.9835.608
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
CHEBI:15477PubChem0.9851.651
NSC112207PubChem0.9785.55
3-hydroxypropionyl-coenzyme APubChem0.9839.597
C05258PubChem0.91021.94
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C16469PubChem0.9893.687
H(+)PubChem0.92.01588
C05275PubChem0.9919.768
1,5-dihydro-FADPubChem0.9787.566
C11947PubChem0.9935.767
C05260PubChem0.9993.889
2-methylacetoacetyl-CoAPubChem0.9865.634
acryloyl-CoAPubChem0.9821.581
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
C14145PubChem0.9911.659
3-hydroxydecanoyl-CoAPubChem0.9937.783
3-hydroxyadipyl-CoAPubChem0.9911.659
FADH2PubChem0.9787.566
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C11946PubChem0.9917.752
alpha-methylbutyryl-CoAPubChem0.9851.651