Rv1346

Tuberculist information
Gene namembtN
Protein functionAcyl-CoA dehydrogenase MbtN
Functional category(tuberculist)lipid metabolism
Gene location(kb)1510.85
Molecular mass(da)41180.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 386
	  		  	1    MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLGVCGVFDAKWATDARPD   60
			  	61   VGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYLRDICDQAIRGAAVLCIGA  120
			  	121  SEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSRHGNVA  180
			  	181  VVAVPAAQVSVQTPYRKVGAGPLDTAAVCIDTWVPADALVARAGTGLAAISWGLAHERMS  240
			  	241  IAGQIAASCQRAIGITLARMMSRRQFGQTLFEHQALRLRMADLQARVDLLRYALHGIAEQ  300
			  	301  GRLELRTAAAVKVTAARLGEEVISECMHIFGGAGYLVDETTLGKWWRDMKLARVGGGTDE  360
			  	361  VLWELVAAGMTPDHDGYAAVVGASKA

Known structures in the PDB
PDB ID4M6Z
Total residue count778
Number of chains2
MethodX-RAY
Resolution2.3
1 39 77 115 153 191 229 267 305 343 381 Range: 5 to 113  |  Coverage: 27% Acyl-CoA_dh_N Range: 117 to 169  |  Coverage: 13% Acyl-CoA_dh_M Range: 224 to 371  |  Coverage: 38% Acyl-CoA_dh_1 Range: 3 to 371  |  Coverage: 95% 1 Range: 1 to 377  |  Coverage: 97% 1 Range: 224 to 371  |  Coverage: 38% 2 Range: 104 to 236  |  Coverage: 34% 3 Range: 5 to 113  |  Coverage: 27% 4 Range: 1 to 374  |  Coverage: 96% 5
Number of amino acids : 386
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027715-113
Acyl-CoA_dh_MPF02770117-169
Acyl-CoA_dh_1PF00441224-371
Mtb Structural Proteome models
Model Number1
Model nameRv1346
Template2D29    APDBCREDO
Template coverage7_384
Template Identity(%)24.9
Model coverage(%)95.3
Normalized DOPE score-0.273

Structure Models from Chopin
Model Number1
Profile1.10.540.10, 2.40.110.10
Click for model details
zscore52.04
Residue begin1
Residue end377
Model Number2
Profilea.29.3.1
Click for model details
zscore36.18
Residue begin224
Residue end371
Model Number3
Profile2.40.110.10
Click for model details
zscore17.1
Residue begin104
Residue end236
Model Number4
Profile1.10.540.10
Click for model details
zscore16.21
Residue begin5
Residue end113
Model Number5
Profilee.6.1.1
Click for model details
zscore14.49
Residue begin1
Residue end374
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1346Gene nameConfidence Score
Rv1344mbtL0.977
Rv1345mbtM0.977
Rv0673echA40.915
Rv2486echA140.911
Rv3029cfixA0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
c1137PubChem0.9875.672
coenzyme APubChem0.9767.534
crotonyl-CoAPubChem0.9835.608
Co-APubChem0.9767.534
phosphatePubChem0.996.9872
[(2S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[[[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[2-(1-oPubChem0.9833.592
5-methylhex-4-enoyl-CoAPubChem0.9877.688
butyryl phosphatePubChem0.9168.085
3-hydroxybutyryl-CoAPubChem0.9853.623
hydroxyl radicalsPubChem0.917.0073
C16468PubChem0.9875.672
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79
butyryl-CoAPubChem0.9837.624