Rv1345

Tuberculist information
Gene namembtM
Protein functionProbable fatty acyl-AMP ligase MbtM
Functional category(tuberculist)lipid metabolism
Gene location(kb)1509.28
Molecular mass(da)53957.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 521
	  		  	1    MSELAAVLTRSMQASAGDLMVLDRETSLWCRHPWPEVHGLAESVAAWLLDHDRPAAVGLV   60
			  	61   GEPTVELVAAIQGAWLAGAAVSILPGPVRGANDQRWADATLTRFLGIGVRTVLSQGSYLA  120
			  	121  RLRSVDTAGVTIGDLSTAAHTNRSATPVASEGPAVLQGTAGSTGAPRTAILSPGAVLSNL  180
			  	181  RGLNQRVGTDAATDVGCSWLPLYHDMGLAFVLSAALAGAPLWLAPTTAFTASPFRWLSWL  240
			  	241  SDSGATMTAAPNFAYNLIGKYARRVSEVDLGALRVTLNGGEPVDCDGLTRFAEAMAPFGF  300
			  	301  DAGAVLPSYGLAESTCAVTVPVPGIGLLADRVIDGSGAHKHAVLGNPIPGMEVRISCGDQ  360
			  	361  AAGNASREIGEIEIRGASMMAGYLGQQPIDPDDWFATGDLGYLGAGGLVVCGRAKEVISI  420
			  	421  AGRNIFPTEVELVAAQVRGVREGAVVALGTGDRSTRPGLVVAAEFRGPDEANARAELIQR  480
			  	481  VASECGIVPSDVVFVSPGSLPRTSSGKLRRLAVRRSLEMAD

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 10 to 421  |  Coverage: 78% AMP-binding Range: 1 to 517  |  Coverage: 99% 1 Range: 1 to 521  |  Coverage: 99% 1 Range: 345 to 413  |  Coverage: 13% 2
Number of amino acids : 521
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF0050110-421
Mtb Structural Proteome models
Model Number1
Model nameRv1345
Template1T5H    XPDBCREDO
Template coverage1_502
Template Identity(%)20.7
Model coverage(%)99.0
Normalized DOPE score0.386

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore34.06
Residue begin1
Residue end521
Model Number2
Profile2.30.38.10
Click for model details
zscore10.88
Residue begin345
Residue end413
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1345Gene nameConfidence Score
Rv1344mbtL0.979
Rv1346mbtN0.977
Rv1346mbtN0.977
Rv1346mbtN0.977
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions