Rv0228

Tuberculist information
Gene nameRv0228
Protein functionProbable integral membrane acyltransferase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)273.055
Molecular mass(da)43295.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 407
	  		  	1    MGPADESGAPIRPQTPHRHTVLVTNGQVVGGTRGFLPAVEGMRACAAVGVVVTHVAFQTG   60
			  	61   HSSGVGGRLFGRFDLAVAVFFAVSGFLLWRGHAAAARDLRSHPRTGPYLRSRVARIMPAY  120
			  	121  VVAVVVILSLLPDADHASLTVWLANLTLTQIYVPLTLTGGLTQMWSLSVEVAFYAALPVL  180
			  	181  ALLGRRIPVGARVPAIAALAALSWAWGWLPLDAGSGINPLTWPPAFFSWFAAGMLLAEWA  240
			  	241  YSPVGLPHRWARRRVAMAVTALLGYLVAASPLAGPEGLVPGTAAQFAVKTAMGSLVAFAL  300
			  	301  VAPLVLDRPDTSHRLLGSPAMVTLGRWSYGLFIWHLAALAMVFPVIGAFPFTGRMPTVLV  360
			  	361  LTLIFGFAIAAVSYALVESPCREALRRWERRNEPISVGELQADAIAP

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 36 to 377  |  Coverage: 83% Acyl_transf_3 Range: 117 to 377  |  Coverage: 63% 1
Number of amino acids : 407
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl_transf_3PF0175736-377
Mtb Structural Proteome models
Model Number1
Model nameRv0228
Template1M56    APDBCREDO
Template coverage230_511
Template Identity(%)12.6
Model coverage(%)63.9
Normalized DOPE score1.278

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0228Gene nameConfidence Score
Rv2486echA140.92
Rv1070cechA80.909
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
2-naphthoyl-CoAPubChem0.9921.699
3-hydroxybutyryl-CoAPubChem0.9853.623
succinyl-CoAPubChem0.9867.607
C01144PubChem0.9853.623
c0888PubChem0.9933.751
C11949PubChem0.9877.688
c1113PubChem0.91021.77
acetyl-CoAPubChem0.9809.571
glutaryl coenzyme APubChem0.9881.633
glutaryl-CoAPubChem0.9881.633
benzoyl-CoAPubChem0.9871.64
C11948PubChem0.9933.751
c0889PubChem0.9877.688
C14119PubChem0.91021.77