Rv3551

Tuberculist information
Gene nameRv3551
Protein functionPossible CoA-transferase (alpha subunit)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3989.9
Molecular mass(da)31690.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 292
	  		  	1    VPDKRTALDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDVTDLTVVTYGGPDLGLL   60
			  	61   CSAGKVKRVYYGFVSLDSPPFYDPWFAHARTSGAIEAREMDEGMLRCGLQAAAQRLPFLP  120
			  	121  IRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPALRLDAAFAHLNLGDSHGNAAY  180
			  	181  TGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQALLVNRMMVDAIVEAPGGAHFT  240
			  	241  TAAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSGTEADYQAAVHNFGASR

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 5 to 233  |  Coverage: 78% CoA_trans Range: 3 to 292  |  Coverage: 98% 1 Range: 1 to 292  |  Coverage: 99% 1
Number of amino acids : 292
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CoA_transPF011445-233
Mtb Structural Proteome models
Model Number1
Model nameRv3551
Template1POI    APDBCREDO
Template coverage2_300
Template Identity(%)26.9
Model coverage(%)98.6
Normalized DOPE score-0.218

Structure Models from Chopin
Model Number1
Profilec.124.1.2 - 3.40.1080.10
Click for model details
zscore6.27
Residue begin1
Residue end292
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3551Gene nameConfidence Score
Rv3552Rv35520.999
Rv3550echA200.996
Rv3562fadE310.981
Rv3562fadE310.981
Rv3562fadE310.981
Rv3560cfadE300.979
Rv3560cfadE300.979
Rv3560cfadE300.979
Rv3563fadE320.968
Rv3563fadE320.968
Rv3564fadE330.939
Rv3564fadE330.939
Rv1933cfadE180.922
Rv1933cfadE180.922
Rv3543cfadE290.921
Rv3543cfadE290.921
Rv3543cfadE290.921
Rv1934cfadE170.92
Rv3553Rv35530.92
Rv1934cfadE170.92
Rv1934cfadE170.92
Rv2724cfadE200.91
Rv2789cfadE210.91
Rv2789cfadE210.91
Rv0752cfadE90.91
Rv2789cfadE210.91
Rv0752cfadE90.91
Rv2724cfadE200.91
Rv0752cfadE90.91
Rv2724cfadE200.91
Rv0215cfadE30.909
Rv0215cfadE30.909
Rv0215cfadE30.909
Rv3504fadE260.907
Rv3504fadE260.907
Rv3504fadE260.907
Rv0244cfadE50.903
Rv0244cfadE50.903
Rv0244cfadE50.903
Rv0244cfadE50.903
Rv0244cfadE50.903
Rv3139fadE240.902
Rv3139fadE240.902
Rv3139fadE240.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
succinyl-CoAPubChem0.908867.607
geranic acidPubChem0.9168.233
2-naphthoyl-CoAPubChem0.9921.699
2-naphthoic acidPubChem0.9172.18
naphthyl-2-methyl-succinyl-CoAPubChem0.91007.79