Rv0751c

Tuberculist information
Gene namemmsB
Protein functionProbable 3-hydroxyisobutyrate dehydrogenase MmsB (hibadh)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)842.347
Molecular mass(da)29679
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 294
	  		  	1    MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADV   60
			  	61   VITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSG  120
			  	121  GVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQI  180
			  	181  AIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTAL  240
			  	241  MNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRARADA

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 1 to 160  |  Coverage: 54% NAD_binding_2 Range: 162 to 288  |  Coverage: 42% NAD_binding_11 Range: 1 to 292  |  Coverage: 98% 1 Range: 1 to 292  |  Coverage: 98% 1 Range: 159 to 294  |  Coverage: 45% 2 Range: 1 to 92  |  Coverage: 30% 3
Number of amino acids : 294
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NAD_binding_2PF034461-160
NAD_binding_11PF14833162-288
Mtb Structural Proteome models
Model Number1
Model nameRv0751c
Template2H78    APDBCREDO
Template coverage1_296
Template Identity(%)45.9
Model coverage(%)99.0
Normalized DOPE score-0.377

Structure Models from Chopin
Model Number1
Profilea.100.1.1, c.2.1.6
Click for model details
zscore59.21
Residue begin1
Residue end292
Model Number2
Profilea.100.1.1
Click for model details
zscore28.17
Residue begin159
Residue end294
Model Number3
Profilec.5.1.1
Click for model details
zscore9.86
Residue begin1
Residue end92
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0751cGene nameConfidence Score
Rv0753cmmsA0.996
Rv1071cechA90.992
Rv1071cechA90.992
Rv0458Rv04580.936
Rv0752cfadE90.93
Rv0752cfadE90.93
Rv0752cfadE90.93
Rv2858caldC0.926
Rv0768aldA0.921
Rv0147Rv01470.916
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.971663.425
3-hydroxyisobutyratePubChem0.964104.105
methylmalonate semialdehydePubChem0.954102.089
propionyl-CoAPubChem0.911823.597
glutamatePubChem0.902147.129
n-propionyl-CoAPubChem0.9823.597
coenzyme APubChem0.9767.534
beta-aminoisobutyric acidPubChem0.9103.12
bicarbonatePubChem0.962.0248
protiumPubChem0.92.01576
alpha-ketoglutaratePubChem0.9146.098
hydroxyl radicalsPubChem0.917.0073
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
Co-APubChem0.9767.534
(S)-beta-aminoisobutyratePubChem0.9103.12
deuteriumPubChem0.92.01588
C06002PubChem0.9102.089
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
H(+)PubChem0.92.01588
SeMetPubChem0.704196.106
selenomethioninePubChem0.704196.106