Rv3540c

Tuberculist information
Gene nameltp2
Protein functionProbable lipid transfer protein or keto acyl-CoA thiolase Ltp2
Functional category(tuberculist)lipid metabolism
Gene location(kb)3979.5
Molecular mass(da)40555.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 386
	  		  	1    VLSGQAAIVGIGATDFSKNSGRSELRLAAEAVLDALADAGLSPTDVDGLTTFTMDTNTEI   60
			  	61   AVARAAGIGELTFFSKIHYGGGAACATVQHAAMAVATGVADVVVAYRAFNERSGMRFGQV  120
			  	121  QTRLTENADSTGVDNSFSYPHGLSTPAAQVAMIARRYMHLSGATSRDFGAVSVADRKHAA  180
			  	181  NNPKAYFYGKPITIEDHQNSRWIAEPLRLLDCCQETDGAVAIVVTSAARARDLKQRPVVI  240
			  	241  EAAAQGCSPDQYTMVSYYRPELDGLPEMGLVGRQLWAQSGLTPADVQTAVLYDHFTPFTL  300
			  	301  IQLEELGFCGKGEAKDFIADGAIEVGGRLPINTHGGQLGEAYIHGMNGIAEGVRQLRGTS  360
			  	361  VNPVAGVEHVLVTAGTGVPTSGLILG

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 5 to 227  |  Coverage: 57% Thiolase_N Range: 255 to 368  |  Coverage: 29% Ketoacyl-synt_C Range: 1 to 384  |  Coverage: 99% 1 Range: 1 to 364  |  Coverage: 94% 1
Number of amino acids : 386
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF001085-227
Ketoacyl-synt_CPF02801255-368
Mtb Structural Proteome models
Model Number1
Model nameRv3540c
Template1WDK    CPDBCREDO
Template coverage3_388
Template Identity(%)15.9
Model coverage(%)99.2
Normalized DOPE score0.524

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore7.31
Residue begin1
Residue end364
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3540cGene nameConfidence Score
Rv3541cRv3541c0.996
Rv3543cfadE290.995
Rv3542cRv3542c0.995
Rv3542cRv3542c0.995
Rv3543cfadE290.995
Rv3543cfadE290.995
Rv3544cfadE280.979
Rv3544cfadE280.979
Rv3545ccyp1250.975
Rv3560cfadE300.906
Rv3560cfadE300.906
Rv3560cfadE300.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions