Rv1144

Tuberculist information
Gene nameRv1144
Protein functionProbable short-chain type dehydrogenase/reductase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1271.16
Molecular mass(da)25787.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 250
	  		  	1    MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVVVDLRGDDVVGGLGDRARFAQADVTDE   60
			  	61   AAVSNALELADSLGPVRVVVNCAGTGNAIRVLSRDGVFPLAAFRKIVDINLVGTFNVLRL  120
			  	121  GAERIAKTEPIGEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARDLASKLIR  180
			  	181  VVTIAPGLFDTPLLASLPAEAKASLGQQVPHPSRLGNPDEYGALVLHIIENPMLNGEVIR  240
			  	241  LDGAIRMAPR

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 6 to 175  |  Coverage: 67% adh_short Range: 8 to 250  |  Coverage: 96% 1 Range: 1 to 250  |  Coverage: 99% 1
Number of amino acids : 250
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
adh_shortPF001066-175
Mtb Structural Proteome models
Model Number1
Model nameRv1144
Template1UAY    APDBCREDO
Template coverage5_242
Template Identity(%)60.5
Model coverage(%)96.8
Normalized DOPE score-0.942

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore22.05
Residue begin1
Residue end250
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1144Gene nameConfidence Score
Rv1323fadA40.972
Rv1323fadA40.972
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.951663.425
2-methyl-3-hydroxybutyryl-CoAPubChem0.92867.65
2-methylacetoacetyl-CoAPubChem0.905865.634
reduced nicotinamide adenine dinucleotidePubChem0.901665.441
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
CHEBI:15449PubChem0.9867.65
AR-1L3756PubChem0.9865.634