Rv0952

Tuberculist information
Gene namesucD
Protein functionProbable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1063.14
Molecular mass(da)31228.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 303
	  		  	1    MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRL   60
			  	61   IKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYA  120
			  	121  WAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIGLVSKSGTLTYQMMFELR  180
			  	181  DLGFSTAIGIGGDPVIGTTHIDAIEAFERDPDTKLIVMIGEIGGDAEERAADFIKTNVSK  240
			  	241  PVVGYVAGFTAPEGKTMGHAGAIVSGSSGTAAAKQEALEAAGVKVGKTPSATAALAREIL  300
			  	301  LSL

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 9 to 111  |  Coverage: 33% CoA_binding Range: 165 to 284  |  Coverage: 39% Ligase_CoA Range: 5 to 299  |  Coverage: 97% 1 Range: 1 to 303  |  Coverage: 99% 1 Range: 138 to 303  |  Coverage: 54% 2 Range: 165 to 284  |  Coverage: 39% 3 Range: 9 to 111  |  Coverage: 33% 4 Range: 22 to 144  |  Coverage: 40% 5
Number of amino acids : 303
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CoA_bindingPF026299-111
Ligase_CoAPF00549165-284
Mtb Structural Proteome models
Model Number1
Model nameRv0952
Template2SCU    APDBCREDO
Template coverage1_286
Template Identity(%)52.3
Model coverage(%)97.0
Normalized DOPE score-1.106

Structure Models from Chopin
Model Number1
Profilec.2.1.8, c.23.4.1 - 3.40.50.261, 3.40.50.720
Click for model details
zscore53.06
Residue begin1
Residue end303
Model Number2
Profile3.40.50.261
Click for model details
zscore23.72
Residue begin138
Residue end303
Model Number3
Profilec.23.4.1
Click for model details
zscore18.44
Residue begin165
Residue end284
Model Number4
Profilec.2.1.8 - 3.40.50.720
Click for model details
zscore12.21
Residue begin9
Residue end111
Model Number5
Profilec.2.1.8 - 3.40.50.720
Click for model details
zscore11.79
Residue begin22
Residue end144
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0952Gene nameConfidence Score
Rv0951sucC0.999
Rv0951sucC0.999
Rv2215dlaT0.998
Rv3318sdhA0.998
Rv2215dlaT0.998
Rv3318sdhA0.998
Rv3319sdhB0.998
Rv3319sdhB0.998
Rv2215dlaT0.998
Rv1552frdA0.994
Rv1552frdA0.994
Rv1553frdB0.994
Rv1553frdB0.994
Rv1248cRv1248c0.993
Rv1248cRv1248c0.993
Rv1248cRv1248c0.993
Rv0248cRv0248c0.992
Rv0248cRv0248c0.992
Rv1098cfum0.991
Rv1240mdh0.991
Rv1240mdh0.991
Rv1098cfum0.991
Rv2454cRv2454c0.99
Rv2455cRv2455c0.988
Rv2455cRv2455c0.988
Rv1493mutB0.974
Rv1493mutB0.974
Rv2445cndkA0.973
Rv1310atpD0.969
Rv1310atpD0.969
Rv1310atpD0.969
Rv2495cbkdC0.966
Rv2495cbkdC0.966
Rv2495cbkdC0.966
Rv0247cRv0247c0.964
Rv0247cRv0247c0.964
Rv3316sdhC0.963
Rv1308atpA0.954
Rv1308atpA0.954
Rv1308atpA0.954
Rv3150nuoF0.948
Rv3150nuoF0.948
Rv3150nuoF0.948
Rv2995cleuB0.948
Rv1309atpG0.946
Rv3148nuoD0.942
Rv1555frdD0.936
Rv0896gltA20.935
Rv3028cfixB0.934
Rv3028cfixB0.934
Rv3356cfolD0.916
Rv3356cfolD0.916
Rv1438tpi0.915
Rv2614cthrS0.914
Rv2614cthrS0.914
Rv2614cthrS0.914
Rv1023eno0.912
Rv1023eno0.912
Rv1436gap0.91
Rv1436gap0.91
Rv0957purH0.907
Rv0957purH0.907
Rv1492mutA0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.97396.9872
Co-APubChem0.969767.534
coenzyme APubChem0.969767.534
adenosine diphosphatePubChem0.969427.201
succinyl-CoAPubChem0.956867.607
succinatePubChem0.954118.088
citratePubChem0.943192.124
oxaloacetatePubChem0.93132.072
alpha-ketoglutaratePubChem0.93146.098
acetyl-CoAPubChem0.914809.571
carbon dioxidePubChem0.90644.0095
ubiquinolPubChem0.903320.423
NAD+PubChem0.9663.425
CoQPubChem0.9318.407
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
suc-coaPubChem0.9867.607
ubiquinonesPubChem0.9250.29
adenosine triphosphatePubChem0.9507.181
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
AcCoAPubChem0.9809.571
ubiquinol-1PubChem0.9252.306
fumaratePubChem0.9116.072
deuteriumPubChem0.92.01588
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
glycerolPubChem0.76692.0938
magnesiumPubChem0.73824.305
2-amino-3-(1-phosphonoimidazol-4-yl)propanoic acidPubChem0.702235.134
hydron sulfatePubChem0.702196.157
hydron diphosphatePubChem0.702391.981
sulfatePubChem0.70296.0626