Rv3316

Tuberculist information
Gene namesdhC
Protein functionProbable succinate dehydrogenase (cytochrome B-556 subunit) SdhC (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3704.1
Molecular mass(da)12837.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 112
	  		  	1    MWSWVCHRISGATIFFFLFVHVLDAAMLRVSPQTYNAVLATYKTPIVGLMEYGLVAAVLF   60
			  	61   HALNGIRVILIDFWSEGPRYQRLMLWIIGSVFLLLMVPAGVVVGIHMWEHFR

Known structures in the PDB
No Known structures
1 12 23 34 45 56 67 78 89 100 111 Range: 1 to 97  |  Coverage: 85% Sdh_cyt Range: 3 to 103  |  Coverage: 89% 1 Range: 1 to 111  |  Coverage: 98% 1
Number of amino acids : 112
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sdh_cytPF011271-97
Mtb Structural Proteome models
Model Number1
Model nameRv3316
Template1NEK    CPDBCREDO
Template coverage26_128
Template Identity(%)23.8
Model coverage(%)89.3
Normalized DOPE score1.02

Structure Models from Chopin
Model Number1
Profilef.21.2.2 - 1.20.1300.10
Click for model details
zscore4.66
Residue begin1
Residue end111
Binding pockets
STRING
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Protein interacting with Rv3316Gene nameConfidence Score
Rv3317sdhD0.999
Rv3319sdhB0.999
Rv3319sdhB0.999
Rv3318sdhA0.998
Rv3318sdhA0.998
Rv0952sucD0.963
Rv0952sucD0.963
Rv0951sucC0.946
Rv0951sucC0.946
Rv1098cfum0.944
Rv1098cfum0.944
Rv0248cRv0248c0.908
Rv0248cRv0248c0.908
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
succinatePubChem0.9118.088
fumaratePubChem0.9116.072