Rv0951

Tuberculist information
Gene namesucC
Protein functionProbable succinyl-CoA synthetase (beta chain) SucC (SCS-beta)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1061.96
Molecular mass(da)40925.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 387
	  		  	1    MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVK   60
			  	61   YAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEYYLSFLLDRANRTYLAMCSVE  120
			  	121  GGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGHLPAEVLDTAAVTIAKLWELF  180
			  	181  VAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEH  240
			  	241  DLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLD  300
			  	301  VVLGDQQVKSVFVNVFGGITSCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRIL  360
			  	361  TEANHPLVTLVATMDEAADKAAELASA

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 2 to 195  |  Coverage: 49% ATP-grasp_2 Range: 254 to 383  |  Coverage: 33% Ligase_CoA Range: 1 to 385  |  Coverage: 99% 1 Range: 1 to 386  |  Coverage: 99% 1 Range: 2 to 195  |  Coverage: 49% 2 Range: 254 to 383  |  Coverage: 33% 3
Number of amino acids : 387
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ATP-grasp_2PF084422-195
Ligase_CoAPF00549254-383
Mtb Structural Proteome models
Model Number1
Model nameRv0951
Template2SCU    BPDBCREDO
Template coverage1_385
Template Identity(%)40.0
Model coverage(%)99.2
Normalized DOPE score-0.106

Structure Models from Chopin
Model Number1
Profilec.23.4.1, d.142.1.4 - 3.30.1490.20, 3.30.470.20, 3.40.50.261
Click for model details
zscore57.95
Residue begin1
Residue end386
Model Number2
Profiled.142.1.4
Click for model details
zscore43.43
Residue begin2
Residue end195
Model Number3
Profile3.40.50.261
Click for model details
zscore14.28
Residue begin254
Residue end383
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0951Gene nameConfidence Score
Rv2215dlaT0.999
Rv2215dlaT0.999
Rv0952sucD0.999
Rv2215dlaT0.999
Rv0952sucD0.999
Rv3318sdhA0.998
Rv3319sdhB0.998
Rv3319sdhB0.998
Rv3318sdhA0.998
Rv1248cRv1248c0.993
Rv1248cRv1248c0.993
Rv1248cRv1248c0.993
Rv2455cRv2455c0.992
Rv2455cRv2455c0.992
Rv1552frdA0.992
Rv1552frdA0.992
Rv0248cRv0248c0.992
Rv1553frdB0.992
Rv0248cRv0248c0.992
Rv1553frdB0.992
Rv2454cRv2454c0.991
Rv1240mdh0.986
Rv1240mdh0.986
Rv1493mutB0.984
Rv1493mutB0.984
Rv1098cfum0.971
Rv1098cfum0.971
Rv1555frdD0.969
Rv0247cRv0247c0.964
Rv0247cRv0247c0.964
Rv1308atpA0.952
Rv1308atpA0.952
Rv1308atpA0.952
Rv0896gltA20.95
Rv2495cbkdC0.95
Rv2495cbkdC0.95
Rv2495cbkdC0.95
Rv3316sdhC0.946
Rv2445cndkA0.943
Rv0462lpdC0.942
Rv0462lpdC0.942
Rv0462lpdC0.942
Rv2995cleuB0.936
Rv1310atpD0.925
Rv1310atpD0.925
Rv1310atpD0.925
Rv3317sdhD0.922
Rv2614cthrS0.92
Rv2614cthrS0.92
Rv1492mutA0.92
Rv2614cthrS0.92
Rv3148nuoD0.914
Rv3356cfolD0.908
Rv3356cfolD0.908
Rv1554frdC0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.97496.9872
adenosine diphosphatePubChem0.968427.201
Co-APubChem0.968767.534
coenzyme APubChem0.968767.534
succinyl-CoAPubChem0.957867.607
succinatePubChem0.941118.088
alpha-ketoglutaratePubChem0.929146.098
NAD+PubChem0.915663.425
adenosine triphosphatePubChem0.907507.181
carbon dioxidePubChem0.90644.0095
CoQPubChem0.9318.407
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
ubiquinolPubChem0.9320.423
fumaratePubChem0.9116.072
deuteriumPubChem0.92.01588
ubiquinonesPubChem0.9250.29
H(+)PubChem0.92.01588
ubiquinol-1PubChem0.9252.306
suc-coaPubChem0.9867.607
protiumPubChem0.92.01576
sulfatePubChem0.74896.0626
magnesiumPubChem0.74624.305
2-amino-3-(1-phosphonoimidazol-4-yl)propanoic acidPubChem0.745235.134
hydron diphosphatePubChem0.745391.981
hydron sulfatePubChem0.745196.157
glycerolPubChem0.74192.0938