Rv1554

Tuberculist information
Gene namefrdC
Protein functionProbable fumarate reductase [membrane anchor subunit] FrdC (fumarate dehydrogenase) (fumaric hydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1760.18
Molecular mass(da)14449.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 126
	  		  	1    MSAYRQPVERYWWARRRSYLRFMLREISCIFVAWFVLYLMLVLRAVGAGGNSYQRFLDFS   60
			  	61   ANPVVVVLNVVALSFLLLHAVTWFGSAPRAMVIQVRGRRVPARAVLAGHYAAWLVVSVIV  120
			  	121  AWMVLS

Known structures in the PDB
No Known structures
1 13 25 37 49 61 73 85 97 109 121 Range: 1 to 126  |  Coverage: 99% Fumarate_red_C Range: 2 to 125  |  Coverage: 97% 1
Number of amino acids : 126
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fumarate_red_CPF023001-126
Mtb Structural Proteome models
Model Number1
Model nameRv1554
Template1KF6    CPDBCREDO
Template coverage5_128
Template Identity(%)30.6
Model coverage(%)97.6
Normalized DOPE score1.641

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
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Protein interacting with Rv1554Gene nameConfidence Score
Rv1553frdB0.999
Rv1555frdD0.999
Rv1552frdA0.999
Rv1552frdA0.999
Rv1553frdB0.999
Rv1098cfum0.914
Rv1098cfum0.914
Rv0951sucC0.901
Rv0951sucC0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
fumaratePubChem0.94116.072
succinatePubChem0.923118.088