Rv1555

Tuberculist information
Gene namefrdD
Protein functionProbable fumarate reductase [membrane anchor subunit] FrdD (fumarate dehydrogenase) (fumaric hydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1760.55
Molecular mass(da)13753.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 125
	  		  	1    MTPSTSDARSRRRSAEPFLWLLFSAGGMVTALVAPVLLLLFGLAFPLGWLDAPDHGHLLA   60
			  	61   MVRNPITKLVVLVLVVLALFHAAHRFRFVLDHGLQLGRFDRVIALWCYGMAVLGSATAGW  120
			  	121  MLLTM

Known structures in the PDB
No Known structures
1 13 25 37 49 61 73 85 97 109 121 Range: 7 to 124  |  Coverage: 93% Fumarate_red_D Range: 7 to 122  |  Coverage: 92% 1
Number of amino acids : 125
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fumarate_red_DPF023137-124
Mtb Structural Proteome models
Model Number1
Model nameRv1555
Template1KF6    DPDBCREDO
Template coverage1_118
Template Identity(%)26.7
Model coverage(%)92.0
Normalized DOPE score1.51

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
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Protein interacting with Rv1555Gene nameConfidence Score
Rv1553frdB0.999
Rv1553frdB0.999
Rv1554frdC0.999
Rv1552frdA0.997
Rv1552frdA0.997
Rv0951sucC0.969
Rv0951sucC0.969
Rv0952sucD0.936
Rv0952sucD0.936
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
succinatePubChem0.9118.088
fumaratePubChem0.9116.072