Rv1553

Tuberculist information
Gene namefrdB
Protein functionProbable fumarate reductase [iron-sulfur subunit] FrdB (fumarate dehydrogenase) (fumaric hydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1759.44
Molecular mass(da)27234.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 247
	  		  	1    MMDRIVMEVSRYRPEIESAPTFQAYEVPLTREWAVLDGLTYIKDHLDGTLSFRWSCRMGI   60
			  	61   CGSSGMTINGDPKLACATFLADYLPGPVRVEPMRNFPVIRDLVVDISDFMAKLPSVKPWL  120
			  	121  VRHDEPPVEDGEYRQTPAELDAFKQFSMCINCMLCYSACPVYALDPDFLGPAAIALGQRY  180
			  	181  NLDSRDQGAADRRDVLAAADGAWACTLVGECSTACPKGVDPAGAIQRYKLTAATHALKKL  240
			  	241  LFPWGGG

Known structures in the PDB
No Known structures
1 25 49 73 97 121 145 169 193 217 241 Range: 6 to 111  |  Coverage: 42% Fer2_3 Range: 145 to 219  |  Coverage: 29% Fer4_8 Range: 2 to 243  |  Coverage: 97% 1 Range: 1 to 244  |  Coverage: 98% 1 Range: 104 to 244  |  Coverage: 56% 2 Range: 1 to 130  |  Coverage: 52% 3
Number of amino acids : 247
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fer2_3PF130856-111
Fer4_8PF13183145-219
Mtb Structural Proteome models
Model Number1
Model nameRv1553
Template1KF6    BPDBCREDO
Template coverage3_242
Template Identity(%)50.4
Model coverage(%)97.6
Normalized DOPE score-0.222

Structure Models from Chopin
Model Number1
Profilea.1.2.1, d.15.4.2 - 1.10.1060.10, 3.10.20.30
Click for model details
zscore56.56
Residue begin1
Residue end244
Model Number2
Profilea.1.2.1
Click for model details
zscore29.5
Residue begin104
Residue end244
Model Number3
Profiled.15.4.2
Click for model details
zscore8.49
Residue begin1
Residue end130
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1553Gene nameConfidence Score
Rv1552frdA0.999
Rv1552frdA0.999
Rv1554frdC0.999
Rv1555frdD0.999
Rv0952sucD0.994
Rv0952sucD0.994
Rv3318sdhA0.993
Rv3318sdhA0.993
Rv0951sucC0.992
Rv0951sucC0.992
Rv1098cfum0.989
Rv1098cfum0.989
Rv0248cRv0248c0.906
Rv0248cRv0248c0.906
Rv0234cgabD10.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
fumaratePubChem0.98116.072
succinatePubChem0.96118.088
oxaloacetatePubChem0.752132.072
flavin adenine dinucleotidePubChem0.751785.55
citratePubChem0.726192.124