Tuberculist information
Gene namefrdA
Protein functionProbable fumarate reductase [flavoprotein subunit] FrdA (fumarate dehydrogenase) (fumaric hydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1757.68
Molecular mass(da)63763.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 583
	  		  	1    MTAQHNIVVIGGGGAGLRAAIAIAETNPHLDVAIVSKVYPMRSHTVSAEGGAAAVTGDDD   60
			  	61   SLDEHAHDTVSGGDWLCDQDAVEAFVAEAPKELVQLEHWGCPWSRKPDGRVAVRPFGGMK  120
			  	121  KLRTWFAADKTGFHLLHTLFQRLLTYSDVMRYDEWFATTLLVDDGRVCGLVAIELATGRI  180
			  	181  ETILADAVILCTGGCGRVFPFTTNANIKTGDGMALAFRAGAPLKDMEFVQYHPTGLPFTG  240
			  	241  ILITEAARAEGGWLLNKDGYRYLQDYDLGKPTPEPRLRSMELGPRDRLSQAFVHEHNKGR  300
			  	301  TVDTPYGPVVYLDLRHLGADLIDAKLPFVRELCRDYQHIDPVVELVPVRPVVHYMMGGVH  360
			  	361  TDINGATTLPGLYAAGETACVSINGANRLGSNSLPELLVFGARAGRAAADYAARHQKSDR  420
			  	421  GPSSAVRAQARTEALRLERELSRHGQGGERIADIRADMQATLESAAGIYRDGPTLTKAVE  480
			  	481  EIRVLQERFATAGIDDHSRTFNTELTALLELSGMLDVALAIVESGLRREESRGAHQRTDF  540
			  	541  PNRDDEHFLAHTLVHRESDGTLRVGYLPVTITRWPPGERVYGR
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAD_binding_2PF008906-394
Succ_DH_flav_CPF02910455-581
Mtb Structural Proteome models
Model Number1
Model nameRv1552
Template1KF6    APDBCREDO
Template coverage2_576
Template Identity(%)54.8
Model coverage(%)98.6
Normalized DOPE score-0.994

Structure Models from Chopin
Model Number1
Profile1.20.58.100, 3.50.50.60, 3.90.700.10, 4.10.80.40
Click for model details
zscore97.58
Residue begin1
Residue end581
Model Number2
Profilea.7.3.1
Click for model details
zscore27.56
Residue begin438
Residue end583
Model Number3
Profilea.138.1.3, d.168.1.1 - 1.10.1130.10, 3.50.50.60, 3.90.700.10
Click for model details
zscore26.35
Residue begin1
Residue end414
Model Number4
Profile3.90.700.10
Click for model details
zscore20.5
Residue begin228
Residue end354
Model Number5
Profile1.20.58.100
Click for model details
zscore18.35
Residue begin424
Residue end545
Model Number6
Profile4.10.80.40
Click for model details
zscore10.14
Residue begin542
Residue end580
Model Number7
Profilec.5.1.1
Click for model details
zscore4.24
Residue begin1
Residue end97
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1552Gene nameConfidence Score
Rv1553frdB0.999
Rv1553frdB0.999
Rv1554frdC0.999
Rv1555frdD0.997
Rv0952sucD0.994
Rv0952sucD0.994
Rv0951sucC0.992
Rv0951sucC0.992
Rv3319sdhB0.983
Rv3319sdhB0.983
Rv1098cfum0.979
Rv1098cfum0.979
Rv0247cRv0247c0.944
Rv0247cRv0247c0.944
Rv0234cgabD10.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00730DrugBankThiabendazole
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
succinatePubChem0.934118.088
fumaratePubChem0.923116.072