Rv0247c

Tuberculist information
Gene nameRv0247c
Protein functionProbable succinate dehydrogenase [iron-sulfur subunit] (succinic dehydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)298.116
Molecular mass(da)28625.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 248
	  		  	1    MTYSASMRVWRGDESCGELREFTVEVNEGEVVLDVILRLQQTQTPDLAVRWNCKAGKCGS   60
			  	61   CSAEINGKPRLMCMTRMSTFDEDEIVTVTPMRTFPVIRDLVTDVSFNYQKAREIPSFAPP  120
			  	121  KELQPSEYRMAQVDVARSQEFRKCIECFLCQNVCHVVRDHEENKDAFAGPRFLMRIAELE  180
			  	181  MHPLDTRDRRSQAQEEHGLGYCNITKCCTEVCPENIKITDNALIPMKERVADRKYDPVVW  240
			  	241  LGSKLFRR

Known structures in the PDB
No Known structures
1 25 49 73 97 121 145 169 193 217 241 Range: 6 to 109  |  Coverage: 41% Fer2_3 Range: 140 to 216  |  Coverage: 30% Fer4_8 Range: 2 to 234  |  Coverage: 93% 1 Range: 1 to 242  |  Coverage: 97% 1 Range: 102 to 242  |  Coverage: 56% 2 Range: 1 to 110  |  Coverage: 43% 3
Number of amino acids : 248
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fer2_3PF130856-109
Fer4_8PF13183140-216
Mtb Structural Proteome models
Model Number1
Model nameRv0247c
Template2H88    BPDBCREDO
Template coverage9_246
Template Identity(%)23.6
Model coverage(%)93.5
Normalized DOPE score-0.42

Structure Models from Chopin
Model Number1
Profilea.1.2.1, d.15.4.2 - 1.10.1060.10, 3.10.20.30
Click for model details
zscore37.2
Residue begin1
Residue end242
Model Number2
Profilea.1.2.1
Click for model details
zscore25.53
Residue begin102
Residue end242
Model Number3
Profiled.15.4.2
Click for model details
zscore11.53
Residue begin1
Residue end110
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0247cGene nameConfidence Score
Rv0248cRv0248c0.993
Rv0248cRv0248c0.993
Rv0249cRv0249c0.99
Rv0951sucC0.964
Rv0951sucC0.964
Rv0952sucD0.964
Rv0952sucD0.964
Rv1098cfum0.944
Rv1098cfum0.944
Rv1552frdA0.944
Rv1552frdA0.944
Rv3318sdhA0.929
Rv3318sdhA0.929
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
fumaratePubChem0.932116.072
succinatePubChem0.924118.088