Rv3318

Tuberculist information
Gene namesdhA
Protein functionProbable succinate dehydrogenase (flavoprotein subunit) SdhA (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3705
Molecular mass(da)64807.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 590
	  		  	1    LICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVED   60
			  	61   DNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGH  120
			  	121  TRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDLALTQTPSGPVATG  180
			  	181  VIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFH  240
			  	241  QFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLE  300
			  	301  GRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYLMGGI  360
			  	361  PTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAASYAQ  420
			  	421  GHDFVDMPPNPEAMVVGWVSDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALT  480
			  	481  DIHALKERYSRITVHDKGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDY  540
			  	541  PNRDDVNYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYEPKERKY

Known structures in the PDB
No Known structures
1 60 119 178 237 296 355 414 473 532 591 Range: 8 to 401  |  Coverage: 66% FAD_binding_2 Range: 455 to 590  |  Coverage: 22% Succ_DH_flav_C Range: 7 to 590  |  Coverage: 98% 1 Range: 1 to 590  |  Coverage: 99% 1 Range: 455 to 589  |  Coverage: 22% 2 Range: 424 to 545  |  Coverage: 20% 3 Range: 235 to 359  |  Coverage: 21% 4 Range: 5 to 227  |  Coverage: 37% 5
Number of amino acids : 590
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAD_binding_2PF008908-401
Succ_DH_flav_CPF02910455-590
Mtb Structural Proteome models
Model Number1
Model nameRv3318
Template1NEK    APDBCREDO
Template coverage8_588
Template Identity(%)49.6
Model coverage(%)98.8
Normalized DOPE score-0.587

Structure Models from Chopin
Model Number1
Profilea.7.3.1, d.168.1.1 - 1.20.58.100, 3.50.50.60, 3.90.700.10, 4.10.80.40
Click for model details
zscore92.53
Residue begin1
Residue end590
Model Number2
Profilea.7.3.1
Click for model details
zscore21.71
Residue begin455
Residue end589
Model Number3
Profile1.20.58.100
Click for model details
zscore19.76
Residue begin424
Residue end545
Model Number4
Profiled.168.1.1
Click for model details
zscore17.83
Residue begin235
Residue end359
Model Number5
Profilec.3.1.7
Click for model details
zscore5.39
Residue begin5
Residue end227
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3318Gene nameConfidence Score
Rv3319sdhB0.999
Rv3319sdhB0.999
Rv0952sucD0.998
Rv0951sucC0.998
Rv0951sucC0.998
Rv3316sdhC0.998
Rv0952sucD0.998
Rv3317sdhD0.995
Rv1553frdB0.993
Rv1553frdB0.993
Rv1098cfum0.988
Rv1098cfum0.988
Rv0247cRv0247c0.929
Rv0247cRv0247c0.929
Rv1248cRv1248c0.924
Rv1248cRv1248c0.924
Rv1248cRv1248c0.924
Rv1240mdh0.919
Rv1240mdh0.919
Rv0896gltA20.914
Rv0234cgabD10.906
Rv1731gabD20.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00730DrugBankThiabendazole
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
succinatePubChem0.957118.088
fumaratePubChem0.928116.072
flavin adenine dinucleotidePubChem0.754785.55