Rv1731

Tuberculist information
Gene namegabD2
Protein functionPossible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1957.68
Molecular mass(da)55324.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 518
	  		  	1    MPAPSAEVFDRLRNLAAIKDVAARPTRTIDEVFTGKPLTTIPVGTAADVEAAFAEARAAQ   60
			  	61   TDWAKRPVIERAAVIRRYRDLVIENREFLMDLLQAEAGKARWAAQEEIVDLIANANYYAR  120
			  	121  VCVDLLKPRKAQPLLPGIGKTTVCYQPKGVVGVISPWNYPMTLTVSDSVPALVAGNAVVL  180
			  	181  KPDSQTPYCALACAELLYRAGLPRALYAIVPGPGSVVGTAITDNCDYLMFTGSSATGSRL  240
			  	241  AEHAGRRLIGFSAELGGKNPMIVARGANLDKVAKAATRACFSNAGQLCISIERIYVEKDI  300
			  	301  AEEFTRKFGDAVRNMKLGTAYDFSVDMGSLISEAQLKTVSGHVDDATAKGAKVIAGGKAR  360
			  	361  PDIGPLFYEPTVLTNVAPEMECAANETFGPVVSIYPVADVDEAVEKANDTDYGLNASVWA  420
			  	421  GSTAEGQRIAARLRSGTVNVDEGYAFAWGSLSAPMGGMGLSGVGRRHGPEGLLKYTESQT  480
			  	481  IATARVFNLDPPFGIPATVWQKSLLPIVRTVMKLPGRR

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 19 to 481  |  Coverage: 89% Aldedh Range: 11 to 485  |  Coverage: 91% 1 Range: 1 to 518  |  Coverage: 99% 1 Range: 254 to 464  |  Coverage: 40% 2
Number of amino acids : 518
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AldedhPF0017119-481
Mtb Structural Proteome models
Model Number1
Model nameRv1731
Template1WND    APDBCREDO
Template coverage2_474
Template Identity(%)32.8
Model coverage(%)91.5
Normalized DOPE score-0.687

Structure Models from Chopin
Model Number1
Profilec.82.1.1
Click for model details
zscore53.57
Residue begin1
Residue end518
Model Number2
Profile3.40.309.10
Click for model details
zscore44.76
Residue begin254
Residue end464
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1731Gene nameConfidence Score
Rv2589gabT0.931
Rv3318sdhA0.903
Rv3318sdhA0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
succinic semialdehydePubChem0.971102.089
succinatePubChem0.955118.088