SInCRe - Rv2589

Tuberculist information

Gene name	gabT
Protein function	4-aminobutyrate aminotransferase GabT (gamma-amino-N-butyrate transaminase) (GABA transaminase) (glutamate:succinic semialdehyde transaminase) (GABA aminotransferase) (GABA-at)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2916.36
Molecular mass(da)	46780.6
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 449

	  		  	1    VASLQQSRRLVTEIPGPASQALTHRRAAAVSSGVGVTLPVFVARAGGGIVEDVDGNRLID   60
			  	61   LGSGIAVTTIGNSSPRVVDAVRTQVAEFTHTCFMVTPYEGYVAVAEQLNRITPGSGPKRS  120
			  	121  VLFNSGAEAVENAVKIARSYTGKPAVVAFDHAYHGRTNLTMALTAKSMPYKSGFGPFAPE  180
			  	181  IYRAPLSYPYRDGLLDKQLATNGELAAARAIGVIDKQVGANNLAALVIEPIQGEGGFIVP  240
			  	241  AEGFLPALLDWCRKNHVVFIADEVQTGFARTGAMFACEHEGPDGLEPDLICTAKGIADGL  300
			  	301  PLSAVTGRAEIMNAPHVGGLGGTFGGNPVACAAALATIATIESDGLIERARQIERLVTDR  360
			  	361  LTTLQAVDDRIGDVRGRGAMIAVELVKSGTTEPDAGLTERLATAAHAAGVIILTCGMFGN  420
			  	421  IIRLLPPLTIGDELLSEGLDIVCAILADL

Known structures in the PDB

No Known structures

Number of amino acids : 449

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Aminotran_3	PF00202	41-387

Mtb Structural Proteome models

Model Number	1
Model name	Rv2589
Template	1SFF APDB CREDO
Template coverage	3_423
Template Identity(%)	42.8
Model coverage(%)	95.8
Normalized DOPE score	-0.423

Structure Models from Chopin

Model Number	1
Profile	c.67.1.4 Click for model details
zscore	30.31
Residue begin	1
Residue end	449

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2589	Gene name	Confidence Score
Rv3432c	gadB	0.96
Rv0234c	gabD1	0.957
Rv0753c	mmsA	0.94
Rv2858c	aldC	0.94
Rv0768	aldA	0.937
Rv0458	Rv0458	0.935
Rv1731	gabD2	0.931
Rv0860	fadB	0.916
Rv0860	fadB	0.916
Rv0860	fadB	0.916
Rv3602c	panC	0.912
Rv1658	argG	0.908
Rv3601c	panD	0.907
Rv0147	Rv0147	0.907

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
gamma-aminobutyric acidPubChem	0.95	103.12
succinic semialdehydePubChem	0.944	102.089
alpha-ketoglutaratePubChem	0.927	146.098
glutamatePubChem	0.927	147.129
succinatePubChem	0.922	118.088
beta-alaninePubChem	0.906	89.0932
NADPPubChem	0.905	744.413
gamma-aminobutyraldehydePubChem	0.903	87.1204
(S)-beta-aminoisobutyratePubChem	0.903	103.12
beta-aminoisobutyric acidPubChem	0.902	103.12
methylmalonate semialdehydePubChem	0.9	102.089
C06002PubChem	0.9	102.089
deuteriumPubChem	0.9	2.01588
gamma-L-glutamyl-gamma-aminobutyric acidPubChem	0.9	232.234
reduced nicotinamide adenine dinucleotidePubChem	0.9	665.441
H(+)PubChem	0.9	2.01588
NADP(H)PubChem	0.9	745.421
carbon dioxidePubChem	0.9	44.0095
protiumPubChem	0.9	2.01576
gamma-Glu-GABAPubChem	0.9	231.226
NAD+PubChem	0.9	663.425
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
hydroxyl radicalsPubChem	0.9	17.0073
pyridoxal phosphatePubChem	0.7	247.142