Rv3317

Tuberculist information
Gene namesdhD
Protein functionProbable succinate dehydrogenase (hydrophobic membrane anchor subunit) SdhD (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3704.44
Molecular mass(da)16886.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 144
	  		  	1    MSAPVRQRSHDRPASLDNPRSPRRRAGMPNFEKFAWLFMRFSGVVLVFLAIGHVFIMLMW   60
			  	61   DNGVYRLDFNFVAQRWASPFWQTWDLLLLWLAQLHGGNGLRTIIDDYSRKDTTRFWLNSL  120
			  	121  LVLSMLFTLMLGTYVIVTFDPNIS

Known structures in the PDB
No Known structures
1 15 29 43 57 71 85 99 113 127 141 Range: 14 to 137  |  Coverage: 85% Sdh_cyt Range: 13 to 139  |  Coverage: 87% 1 Range: 1 to 144  |  Coverage: 99% 1
Number of amino acids : 144
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sdh_cytPF0112714-137
Mtb Structural Proteome models
Model Number1
Model nameRv3317
Template2BS3    CPDBCREDO
Template coverage102_231
Template Identity(%)22.8
Model coverage(%)87.5
Normalized DOPE score0.965

Structure Models from Chopin
Model Number1
Profilef.21.2.1 - 1.20.950.10
Click for model details
zscore4.89
Residue begin1
Residue end144
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3317Gene nameConfidence Score
Rv3316sdhC0.999
Rv3319sdhB0.998
Rv3319sdhB0.998
Rv3318sdhA0.995
Rv3318sdhA0.995
Rv1098cfum0.939
Rv1098cfum0.939
Rv0951sucC0.922
Rv0951sucC0.922
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
succinatePubChem0.9118.088
fumaratePubChem0.9116.072