Rv3319

Tuberculist information
Gene namesdhB
Protein functionProbable succinate dehydrogenase (iron-sulphur protein subunit) SdhB (succinic dehydrogenase) (fumarate reductase) (fumarate dehydrogenase) (fumaric hydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3706.77
Molecular mass(da)29334.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 263
	  		  	1    MSVEPDVETLDPPLPPVPDGAVMVTVKIARFNPDDPDAFAATGGWQSFRVPCLPSDRLLN   60
			  	61   LLIYIKGYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMRDLLPKKKGKSLTVTVE  120
			  	121  PIRGLPVEKDLVVDMEPFFDAYRAIKPYLITSGNPPTRERIQSPTDRARYDDTTKCILCA  180
			  	181  CCTTSCPVFWHEGSYFGPAAIVNAHRFIFDSRDEAAAERLDILNEVDGVWRCRTTFNCTE  240
			  	241  SCPRGIEVTKAIQEVKRALMFTR

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 25 to 140  |  Coverage: 43% Fer2_3 Range: 172 to 246  |  Coverage: 28% Fer4_8 Range: 28 to 259  |  Coverage: 87% 1 Range: 19 to 263  |  Coverage: 92% 1 Range: 133 to 263  |  Coverage: 49% 2 Range: 11 to 141  |  Coverage: 49% 3
Number of amino acids : 263
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fer2_3PF1308525-140
Fer4_8PF13183172-246
Mtb Structural Proteome models
Model Number1
Model nameRv3319
Template2H88    BPDBCREDO
Template coverage16_242
Template Identity(%)43.2
Model coverage(%)87.8
Normalized DOPE score-0.089

Structure Models from Chopin
Model Number1
Profile1.10.1060.10, 3.10.20.30
Click for model details
zscore46.66
Residue begin19
Residue end263
Model Number2
Profilea.1.2.1
Click for model details
zscore22.91
Residue begin133
Residue end263
Model Number3
Profiled.15.4.2
Click for model details
zscore13.66
Residue begin11
Residue end141
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3319Gene nameConfidence Score
Rv3316sdhC0.999
Rv3318sdhA0.999
Rv3318sdhA0.999
Rv0951sucC0.998
Rv0951sucC0.998
Rv3317sdhD0.998
Rv0952sucD0.998
Rv0952sucD0.998
Rv1098cfum0.992
Rv1098cfum0.992
Rv1552frdA0.983
Rv1552frdA0.983
Rv0248cRv0248c0.98
Rv0248cRv0248c0.98
Rv1248cRv1248c0.951
Rv1248cRv1248c0.951
Rv1248cRv1248c0.951
Rv1240mdh0.95
Rv1240mdh0.95
Rv0896gltA20.933
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
fumaratePubChem0.962116.072
succinatePubChem0.96118.088
oxaloacetatePubChem0.796132.072
flavin adenine dinucleotidePubChem0.767785.55