Rv3148

Tuberculist information
Gene namenuoD
Protein functionProbable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3513.34
Molecular mass(da)48164.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 440
	  		  	1    MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGPQHPSTHGVLRLILEI   60
			  	61   EGETVVEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGI  120
			  	121  TDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTPMFVGFRAREIVLTLFEKITG  180
			  	181  LRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGELLNENAIWKARTQGVGYLD  240
			  	241  LTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVITDDSCDAYGRYMIRVKEMWE  300
			  	301  SMKIVEQCLDKLRPGPTMISDRKLAWPADLQVGPDGLGNSPKHIAKIMGSSMEALIHHFK  360
			  	361  LVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQSVAAMCEGGM  420
			  	421  VADLIAAVASIDPVMGGVDR

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 154 to 440  |  Coverage: 65% Complex1_49kDa Range: 48 to 440  |  Coverage: 89% 1 Range: 48 to 440  |  Coverage: 89% 1
Number of amino acids : 440
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Complex1_49kDaPF00346154-440
Mtb Structural Proteome models
Model Number1
Model nameRv3148
Template2FUG    4PDBCREDO
Template coverage35_409
Template Identity(%)48.4
Model coverage(%)89.1
Normalized DOPE score0.227

Structure Models from Chopin
Model Number1
Profilee.18.1.2
Click for model details
zscore66.01
Residue begin48
Residue end440
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3148Gene nameConfidence Score
Rv3154nuoJ0.999
Rv3151nuoG0.999
Rv3146nuoB0.999
Rv3155nuoK0.999
Rv3151nuoG0.999
Rv3147nuoC0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3149nuoE0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3150nuoF0.999
Rv3157nuoM0.999
Rv3152nuoH0.999
Rv3150nuoF0.999
Rv3158nuoN0.999
Rv3153nuoI0.999
Rv3150nuoF0.999
Rv3145nuoA0.999
Rv0082Rv00820.986
Rv1308atpA0.976
Rv1308atpA0.976
Rv1310atpD0.976
Rv1310atpD0.976
Rv1310atpD0.976
Rv1308atpA0.976
Rv0952sucD0.942
Rv0952sucD0.942
Rv1309atpG0.938
Rv0086hycQ0.917
Rv0951sucC0.914
Rv0951sucC0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
reduced nicotinamide adenine dinucleotidePubChem0.973665.441
CoQPubChem0.926318.407
NAD+PubChem0.91663.425
ubiquinol-1PubChem0.9252.306
ubiquinonesPubChem0.9250.29
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
ubiquinolPubChem0.9320.423
rotenonePubChem0.724394.417
calciumPubChem0.740.078