SInCRe - Rv3156

Tuberculist information

Gene name	nuoL
Protein function	Probable NADH dehydrogenase I (chain L) NuoL (NADH-ubiquinone oxidoreductase chain L)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3522.23
Molecular mass(da)	66135.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 633

	  		  	1    VTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALAAFGVGAMLLADMLGR   60
			  	61   DGLERAIHQQVFTWIPAGGLQVDFGLQIDQLSMCFVLLISGVGSLIHIYSVGYMAEDPDR  120
			  	121  RRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLLIGFWYHKPSAATAAKKAFVM  180
			  	181  NRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAIGLLMLLGACAKSAQVPLQ  240
			  	241  AWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAPTAQLAVVIVGAVTLLFGAI  300
			  	301  IGCAKDDIKRALAASTISQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGSGAVIH  360
			  	361  AMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFAGFFSKDAIIEAALGAGGIRGS  420
			  	421  LLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPHEAPAVMTWPMILLAVGSVFSGG  480
			  	481  LLAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALGVVAVGIAVAYRMYGTAPIPRVAP  540
			  	541  VRVSALTAAARADLYGDAFNEEVFMRPGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNR  600
			  	601  LRQMQTGFARNYALSMLVGAVLVAAALLVVQLW

Known structures in the PDB

No Known structures

Number of amino acids : 633

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Oxidored_q1_N	PF00662	68-129
Oxidored_q1	PF00361	140-411

Mtb Structural Proteome models

Model Number	1
Model name	Rv3156.2
Template	1V54 APDB CREDO
Template coverage	63_473
Template Identity(%)	11.7
Model coverage(%)	68.2
Normalized DOPE score	1.155

Model Number	2
Model name	Rv3156
Template	1V54 APDB CREDO
Template coverage	81_513
Template Identity(%)	15.7
Model coverage(%)	71.9
Normalized DOPE score	1.791

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3156	Gene name	Confidence Score
Rv3149	nuoE	0.999
Rv3158	nuoN	0.999
Rv3151	nuoG	0.999
Rv3150	nuoF	0.999
Rv3152	nuoH	0.999
Rv3150	nuoF	0.999
Rv3145	nuoA	0.999
Rv3153	nuoI	0.999
Rv3150	nuoF	0.999
Rv3154	nuoJ	0.999
Rv3151	nuoG	0.999
Rv3147	nuoC	0.999
Rv3155	nuoK	0.999
Rv3151	nuoG	0.999
Rv3148	nuoD	0.999
Rv3157	nuoM	0.999
Rv3151	nuoG	0.999
Rv3146	nuoB	0.998
Rv3043c	ctaD	0.912

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv3156.2	1	1ya4_CTX_A_1 PDB CREDO	0.765	0.040	0.680	0.000
Rv3156.2	8	1xkk_FMM_A_91 PDB CREDO	0.733	0.058	0.659	0.001
Rv3156.2	8	3spk_TPV_B_100 PDB CREDO	0.714	0.070	0.620	0.001
Rv3156.2	8	1sa1_POD_B_700 PDB CREDO	0.734	0.058	0.619	0.001
Rv3156.2	8	3gp0_NIL_A_1 PDB CREDO	0.666	0.109	0.615	0.002
Rv3156.2	8	1hwk_117_B_1 PDB CREDO	0.680	0.097	0.608	0.002
Rv3156.2	8	1t46_STI_A_3 PDB CREDO	0.635	0.140	0.601	0.002
Rv3156.2	8	1sa1_POD_D_701 PDB CREDO	0.731	0.059	0.599	0.002
Rv3156.2	8	1n49_RIT_B_301 PDB CREDO	0.604	0.174	0.588	0.003
Rv3156.2	8	1n49_RIT_D_401 PDB CREDO	0.641	0.133	0.573	0.003
Rv3156.2	15	1gs4_ZK5_A_1918 PDB CREDO	0.614	0.162	0.571	0.004
Rv3156.2	8	1uwj_BAX_A_1723 PDB CREDO	0.615	0.162	0.566	0.004
Rv3156.2	8	1hwk_117_A_2 PDB CREDO	0.669	0.107	0.564	0.004
Rv3156.2	8	1hwk_117_C_4 PDB CREDO	0.669	0.107	0.564	0.004
Rv3156.2	8	1hwl_FBI_B_1 PDB CREDO	0.682	0.095	0.558	0.004
Rv3156.2	8	1hwl_FBI_D_3 PDB CREDO	0.682	0.096	0.558	0.004
Rv3156.2	15	2cbr_A80_A_201 PDB CREDO	0.557	0.234	0.557	0.004
Rv3156.2	1	3ufn_ROC_A_401 PDB CREDO	0.728	0.061	0.557	0.004
Rv3156.2	8	1c6y_MK1_B_524 PDB CREDO	0.568	0.220	0.552	0.005
Rv3156.2	8	3ut5_LOC_B_502 PDB CREDO	0.695	0.085	0.552	0.005
Rv3156.2	8	2qak_1UN_A_1001 PDB CREDO	0.660	0.115	0.550	0.005
Rv3156.2	1	2f80_017_B_301 PDB CREDO	0.650	0.125	0.550	0.005
Rv3156.2	8	2q64_1UN_B_1001 PDB CREDO	0.659	0.115	0.550	0.005
Rv3156.2	15	3n8z_FLP_A_701 PDB CREDO	0.570	0.216	0.549	0.005
Rv3156.2	1	3sm2_478_A_126 PDB CREDO	0.665	0.110	0.549	0.005
Rv3156.2	8	3gcs_BAX_A_401 PDB CREDO	0.651	0.123	0.549	0.005
Rv3156.2	8	2qxs_RAL_A_600 PDB CREDO	0.548	0.246	0.548	0.005
Rv3156.2	8	2qxs_RAL_B_600 PDB CREDO	0.548	0.247	0.548	0.005
Rv3156.2	8	3sm2_478_A_126 PDB CREDO	0.641	0.134	0.547	0.005
Rv3156.2	8	2pyn_1UN_A_1001 PDB CREDO	0.655	0.119	0.546	0.005
Rv3156.2	1	3oxc_ROC_A_401 PDB CREDO	0.609	0.168	0.545	0.005
Rv3156.2	8	2pym_1UN_A_1001 PDB CREDO	0.654	0.121	0.545	0.005
Rv3156.2	8	1hwl_FBI_A_2 PDB CREDO	0.666	0.109	0.545	0.005
Rv3156.2	8	3ekq_ROC_A_100 PDB CREDO	0.545	0.251	0.545	0.005
Rv3156.2	8	3el9_DR7_A_100 PDB CREDO	0.559	0.231	0.545	0.005
Rv3156.2	8	1hwl_FBI_C_4 PDB CREDO	0.665	0.110	0.544	0.005
Rv3156.2	8	3e22_LOC_D_700 PDB CREDO	0.727	0.061	0.543	0.006
Rv3156.2	8	2q63_1UN_A_1001 PDB CREDO	0.651	0.124	0.543	0.006
Rv3156.2	1	3ndu_ROC_D_100 PDB CREDO	0.542	0.255	0.542	0.006
Rv3156.2	8	3ut5_LOC_D_502 PDB CREDO	0.726	0.062	0.542	0.006
Rv3156.2	15	2ayl_FLP_A_1701 PDB CREDO	0.581	0.202	0.539	0.006
Rv3156.2	8	3e22_LOC_B_700 PDB CREDO	0.721	0.066	0.538	0.006
Rv3156.2	1	2nmy_ROC_A_401 PDB CREDO	0.548	0.247	0.535	0.006
Rv3156.2	8	2xkw_P1B_A_1478 PDB CREDO	0.611	0.167	0.535	0.006
Rv3156.2	8	1hwk_117_D_3 PDB CREDO	0.674	0.102	0.535	0.006
Rv3156.2	1	3bvb_017_B_401 PDB CREDO	0.602	0.177	0.535	0.006
Rv3156.2	8	3el0_1UN_A_201 PDB CREDO	0.565	0.224	0.534	0.006
Rv3156.2	8	4asd_BAX_A_1500 PDB CREDO	0.633	0.141	0.534	0.006
Rv3156.2	1	3ucb_017_A_201 PDB CREDO	0.587	0.195	0.534	0.006
Rv3156.2	15	2w8y_NDR_B_1000 PDB CREDO	0.599	0.180	0.534	0.006
Rv3156.2	8	3spk_TPV_A_100 PDB CREDO	0.815	0.020	0.534	0.006
Rv3156.2	15	3n8z_FLP_B_1701 PDB CREDO	0.620	0.155	0.531	0.007
Rv3156.2	8	1hwi_115_D_3 PDB CREDO	0.711	0.072	0.531	0.007
Rv3156.2	1	2pym_1UN_A_1001 PDB CREDO	0.627	0.148	0.531	0.007
Rv3156.2	1	2qak_1UN_A_1001 PDB CREDO	0.627	0.148	0.531	0.007
Rv3156.2	1	2pyn_1UN_A_1001 PDB CREDO	0.627	0.149	0.530	0.007
Rv3156.2	8	1hwi_115_B_1 PDB CREDO	0.710	0.073	0.530	0.007
Rv3156.2	1	2q64_1UN_B_1001 PDB CREDO	0.626	0.149	0.530	0.007
Rv3156.2	8	3so9_017_A_100 PDB CREDO	0.666	0.110	0.529	0.007
Rv3156.2	1	2q63_1UN_A_1001 PDB CREDO	0.624	0.151	0.528	0.007
Rv3156.2	15	1a27_EST_A_350 PDB CREDO	0.570	0.217	0.528	0.007
Rv3156.2	15	2h42_VIA_C_903 PDB CREDO	0.568	0.219	0.528	0.007
Rv3156.2	1	3k4v_ROC_D_201 PDB CREDO	0.553	0.240	0.528	0.007
Rv3156.2	15	3nt1_NPS_A_5 PDB CREDO	0.616	0.161	0.527	0.007
Rv3156.2	8	3lzv_017_A_200 PDB CREDO	0.557	0.235	0.527	0.007
Rv3156.2	15	2gqg_1N1_A_501 PDB CREDO	0.565	0.223	0.525	0.007
Rv3156.2	8	1c6z_ROC_B_505 PDB CREDO	0.630	0.145	0.525	0.007
Rv3156.2	15	3nt1_NPS_B_4 PDB CREDO	0.613	0.164	0.525	0.007
Rv3156.2	1	3ogq_AB1_A_200 PDB CREDO	0.651	0.123	0.524	0.008
Rv3156.2	8	2nni_MTK_A_501 PDB CREDO	0.603	0.175	0.524	0.008
Rv3156.2	1	3cyx_ROC_A_201 PDB CREDO	0.523	0.283	0.523	0.008
Rv3156.2	8	3ufn_ROC_A_401 PDB CREDO	0.567	0.221	0.523	0.008
Rv3156.2	15	1sqn_NDR_B_2001 PDB CREDO	0.584	0.199	0.523	0.008
Rv3156.2	15	2h42_VIA_B_902 PDB CREDO	0.560	0.230	0.521	0.008
Rv3156.2	8	3bjw_SVR_E_503 PDB CREDO	0.535	0.266	0.520	0.008
Rv3156.2	1	3el4_ROC_A_100 PDB CREDO	0.557	0.234	0.520	0.008
Rv3156.2	15	2x2n_X2N_C_1479 PDB CREDO	0.621	0.154	0.520	0.008
Rv3156.2	15	3h0a_9RA_A_500 PDB CREDO	0.621	0.154	0.520	0.008
Rv3156.2	15	3erd_DES_A_600 PDB CREDO	0.559	0.231	0.519	0.008
Rv3156.2	15	1sqn_NDR_A_1001 PDB CREDO	0.579	0.205	0.519	0.008
Rv3156.2	8	3heg_BAX_A_1 PDB CREDO	0.634	0.141	0.519	0.008
Rv3156.2	8	1uwj_BAX_B_1723 PDB CREDO	0.615	0.161	0.519	0.008
Rv3156.2	8	3ogq_AB1_A_200 PDB CREDO	0.591	0.190	0.518	0.008
Rv3156.2	1	1xkk_FMM_A_91 PDB CREDO	0.661	0.114	0.518	0.008
Rv3156.2	1	2aof_FRD_C_305 PDB CREDO	0.543	0.254	0.518	0.008
Rv3156.2	15	1mx1_THA_D_4 PDB CREDO	0.581	0.202	0.518	0.008
Rv3156.2	8	1rl8_RIT_A_9001 PDB CREDO	0.636	0.138	0.518	0.008
Rv3156.2	15	3k54_1N1_A_1 PDB CREDO	0.535	0.266	0.515	0.009
Rv3156.2	1	3k4v_ROC_B_201 PDB CREDO	0.613	0.164	0.515	0.009
Rv3156.2	1	3tkg_ROC_C_901 PDB CREDO	0.527	0.278	0.515	0.009
Rv3156.2	8	1hsh_MK1_C_402 PDB CREDO	0.529	0.275	0.515	0.009
Rv3156.2	8	1hsh_MK1_A_401 PDB CREDO	0.528	0.276	0.514	0.009
Rv3156.2	1	2qxs_RAL_A_600 PDB CREDO	0.728	0.061	0.514	0.009
Rv3156.2	15	3h52_486_C_4 PDB CREDO	0.553	0.240	0.514	0.009
Rv3156.2	8	3b0w_DGX_B_1 PDB CREDO	0.543	0.254	0.514	0.009
Rv3156.2	15	3ln1_CEL_D_682 PDB CREDO	0.614	0.163	0.513	0.009
Rv3156.2	15	1a28_STR_A_1 PDB CREDO	0.571	0.216	0.512	0.009
Rv3156.2	15	2prg_BRL_B_2 PDB CREDO	0.571	0.216	0.512	0.009
Rv3156.2	8	3cs9_NIL_A_600 PDB CREDO	0.526	0.279	0.512	0.009
Rv3156.2	15	1mx1_THA_F_6 PDB CREDO	0.574	0.211	0.512	0.009
Rv3156.2	1	2qxs_RAL_B_600 PDB CREDO	0.725	0.063	0.511	0.009
Rv3156.2	1	2nnp_ROC_A_401 PDB CREDO	0.548	0.247	0.511	0.009
Rv3156.2	15	1s9p_DES_B_459 PDB CREDO	0.573	0.212	0.511	0.009
Rv3156.2	15	1s9p_DES_C_500 PDB CREDO	0.573	0.212	0.511	0.009
Rv3156.2	15	2fum_MIX_A_539 PDB CREDO	0.549	0.245	0.510	0.009
Rv3156.2	15	2q1v_PDN_A_248 PDB CREDO	0.589	0.192	0.510	0.009
Rv3156.2	1	1t7i_017_A_200 PDB CREDO	0.547	0.248	0.510	0.009
Rv3156.2	8	1jg2_ADN_A_500 PDB CREDO	0.833	0.014	0.510	0.009
Rv3156.2	15	1mx1_THA_E_5 PDB CREDO	0.529	0.274	0.510	0.009
Rv3156.2	1	2xkw_P1B_A_1478 PDB CREDO	0.632	0.143	0.508	0.010
Rv3156.2	8	2y6o_1N1_A_1892 PDB CREDO	0.703	0.079	0.508	0.010
Rv3156.2	8	3cs9_NIL_B_600 PDB CREDO	0.508	0.305	0.508	0.010
Rv3156.2	8	3ggu_017_B_201 PDB CREDO	0.565	0.224	0.508	0.010
Rv3156.2	1	3tl9_ROC_A_401 PDB CREDO	0.542	0.255	0.507	0.010
Rv3156.2	1	3ndt_ROC_A_101 PDB CREDO	0.616	0.160	0.506	0.010
Rv3156.2	15	3aod_RFP_C_2002 PDB CREDO	0.526	0.279	0.506	0.010
Rv3156.2	1	2nnk_ROC_A_401 PDB CREDO	0.556	0.236	0.506	0.010
Rv3156.2	15	2fum_MIX_B_1539 PDB CREDO	0.591	0.190	0.506	0.010
Rv3156.2	15	2prg_BRL_A_1 PDB CREDO	0.562	0.228	0.504	0.010
Rv3156.2	15	1fdu_EST_C_353 PDB CREDO	0.543	0.254	0.503	0.010
Rv3156.2	1	3ndt_ROC_D_100 PDB CREDO	0.552	0.240	0.503	0.010
Rv3156.2	8	1t7j_478_A_200 PDB CREDO	0.633	0.142	0.503	0.010
Rv3156.2	15	1fm6_BRL_D_503 PDB CREDO	0.560	0.230	0.503	0.011
Rv3156.2	15	1ya3_STR_C_3001 PDB CREDO	0.521	0.286	0.502	0.011
Rv3156.2	8	3cs9_NIL_C_600 PDB CREDO	0.530	0.273	0.502	0.011
Rv3156.2	8	3hec_STI_A_1 PDB CREDO	0.672	0.104	0.502	0.011
Rv3156.2	15	3nrr_D16_B_520 PDB CREDO	0.579	0.205	0.502	0.011
Rv3156.2	1	1k6c_MK1_B_902 PDB CREDO	0.537	0.263	0.501	0.011
Rv3156.2	15	1s9p_DES_A_459 PDB CREDO	0.558	0.232	0.501	0.011
Rv3156.2	15	1cqe_FLP_B_2650 PDB CREDO	0.662	0.113	0.500	0.011
Rv3156.2	15	2ayl_FLP_B_2701 PDB CREDO	0.609	0.169	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
reduced nicotinamide adenine dinucleotidePubChem	0.93	665.441
NAD+PubChem	0.923	663.425
ubiquinonesPubChem	0.922	250.29
ubiquinolPubChem	0.919	320.423
CoQPubChem	0.914	318.407
ubiquinol-1PubChem	0.9	252.306
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441