Rv3147

Tuberculist information
Gene namenuoC
Protein functionProbable NADH dehydrogenase I (chain C) NuoC (NADH-ubiquinone oxidoreductase chain C)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3512.63
Molecular mass(da)26932.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 236
	  		  	1    MSPPNQDAQEGRPDSPTAEVVDVRRGMFGVSGTGDTSGYGRLVRQVVLPGSSPRPYGGYF   60
			  	61   DDIVDRLAEALRHERVEFEDAVEKVVVYRDELTLHVRRDLLPRVAQRLRDEPELRFELCL  120
			  	121  GVSGVHYPHETGRELHAVYPLQSITHNRRLRLEVSAPDSDPHIPSLFAIYPTNDWHERET  180
			  	181  YDFFGIIFDGHPALTRIEMPDDWQGHPQRKDYPLGGIPVEYKGAQIPPPDERRGYN

Known structures in the PDB
No Known structures
1 24 47 70 93 116 139 162 185 208 231 Range: 103 to 210  |  Coverage: 45% Complex1_30kDa Range: 66 to 234  |  Coverage: 71% 1 Range: 68 to 236  |  Coverage: 71% 1
Number of amino acids : 236
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Complex1_30kDaPF00329103-210
Mtb Structural Proteome models
Model Number1
Model nameRv3147
Template2FUG    5PDBCREDO
Template coverage2_172
Template Identity(%)30.1
Model coverage(%)71.2
Normalized DOPE score0.348

Structure Models from Chopin
Model Number1
Profiled.307.1.1
Click for model details
zscore26.11
Residue begin68
Residue end236
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3147Gene nameConfidence Score
Rv3150nuoF0.999
Rv3157nuoM0.999
Rv3152nuoH0.999
Rv3150nuoF0.999
Rv3158nuoN0.999
Rv3153nuoI0.999
Rv3150nuoF0.999
Rv3145nuoA0.999
Rv3151nuoG0.999
Rv3146nuoB0.999
Rv3155nuoK0.999
Rv3151nuoG0.999
Rv3148nuoD0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3149nuoE0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3154nuoJ0.998
Rv0082Rv00820.922
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
reduced nicotinamide adenine dinucleotidePubChem0.962665.441
CoQPubChem0.916318.407
ubiquinolPubChem0.912320.423
ubiquinol-1PubChem0.9252.306
NAD+PubChem0.9663.425
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
ubiquinonesPubChem0.9250.29
1,6-hexanediolPubChem0.702118.174
cobaltPubChem0.702117.866