Rv3151

Tuberculist information
Gene namenuoG
Protein functionProbable NADH dehydrogenase I (chain G) NuoG (NADH-ubiquinone oxidoreductase chain G)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3516.75
Molecular mass(da)85392.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 806
	  		  	1    VTQAADTDIRVGQPEMVTLTIDGVEISVPKGTLVIRAAELMGIQIPRFCDHPLLEPVGAC   60
			  	61   RQCLVEVEGQRKPLASCTTVATDDMVVRTQLTSEIADKAQHGVMELLLINHPLDCPMCDK  120
			  	121  GGECPLQNQAMSNGRTDSRFTEAKRTFAKPINISAQVLLDRERCILCARCTRFSDQIAGD  180
			  	181  PFIDMQERGALQQVGIYADEPFESYFSGNTVQICPVGALTGTAYRFRARPFDLVSSPSVC  240
			  	241  EHCASGCAQRTDHRRGKVLRRLAGDDPEVNEEWNCDKGRWAFTYATQPDVITTPLIRDGG  300
			  	301  DPKGALVPTSWSHAMAVAAQGLAAARGRTGVLVGGRVTWEDAYAYAKFARITLGTNDIDF  360
			  	361  RARPHSAEEADFLAARIAGRHMAVSYADLESAPVVLLVGFEPEDESPIVFLRLRKAARRH  420
			  	421  RVPVYTIAPFATGGLHKMSGRLIKTVPGGEPAALDDLATGAVGDLLATPGAVIIVGERLA  480
			  	481  TVPGGLSAAARLADTTGARLAWVPRRAGERGALEAGALPTLLPGGRPLADEVARAQVCAA  540
			  	541  WHIAELPAAAGRDADGILAAAADETLAALLVGGIEPADFADPDAVLAALDATGFVVSLEL  600
			  	601  RHSTVTERADVVFPVAPTTQKAGAFVNWEGRYRTFEPALRGSTLQAGQSDHRVLDALADD  660
			  	661  MGVHLGVPTVEAAREELAALGIWDGKHAAGPHIAATGPTQPEAGEAILTGWRMLLDEGRL  720
			  	721  QDGEPYLAGTARTPVVRLSPDTAAEIGAADGEAVTVSTSRGSITLPCSVTDMPDRVVWLP  780
			  	781  LNSAGSTVHRQLRVTIGSIVKIGAGS

Known structures in the PDB
No Known structures
1 81 161 241 321 401 481 561 641 721 801 Range: 14 to 92  |  Coverage: 9% Fer2_4 Range: 100 to 140  |  Coverage: 4% NADH-G_4Fe-4S_3 Range: 291 to 442  |  Coverage: 18% Molybdopterin Range: 469 to 659  |  Coverage: 23% Molybdopterin Range: 715 to 799  |  Coverage: 10% Molydop_binding Range: 16 to 779  |  Coverage: 94% 1 Range: 16 to 786  |  Coverage: 95% 1 Range: 233 to 806  |  Coverage: 71% 2 Range: 412 to 740  |  Coverage: 40% 3 Range: 1 to 806  |  Coverage: 99% 4 Range: 226 to 292  |  Coverage: 8% 5 Range: 121 to 224  |  Coverage: 12% 6
Number of amino acids : 806
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fer2_4PF1351014-92
NADH-G_4Fe-4S_3PF10588100-140
MolybdopterinPF00384291-442
MolybdopterinPF00384469-659
Molydop_bindingPF01568715-799
Mtb Structural Proteome models
Model Number1
Model nameRv3151
Template2FUG    3PDBCREDO
Template coverage1_760
Template Identity(%)31.2
Model coverage(%)94.7
Normalized DOPE score1.028

Structure Models from Chopin
Model Number1
Profileb.52.2.2, c.81.1.1, d.15.4.2, d.58.1.5
Click for model details
zscore87.11
Residue begin16
Residue end786
Model Number2
Profileb.52.2.2, c.81.1.1 - 1.20.5.460, 2.20.25.90, 2.40.40.20, 3.40.228.10, 3.40.50.740
Click for model details
zscore43.09
Residue begin233
Residue end806
Model Number3
Profile3.40.50.740
Click for model details
zscore17.81
Residue begin412
Residue end740
Model Number4
Profilec.81.1.1
Click for model details
zscore16.69
Residue begin1
Residue end806
Model Number5
Profile2.20.25.90
Click for model details
zscore11.5
Residue begin226
Residue end292
Model Number6
Profiled.58.1.3 - 3.30.70.20
Click for model details
zscore10.03
Residue begin121
Residue end224
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3151Gene nameConfidence Score
Rv3153nuoI0.999
Rv3148nuoD0.999
Rv3154nuoJ0.999
Rv3149nuoE0.999
Rv3155nuoK0.999
Rv3150nuoF0.999
Rv3156nuoL0.999
Rv3150nuoF0.999
Rv3145nuoA0.999
Rv3156nuoL0.999
Rv3150nuoF0.999
Rv3146nuoB0.999
Rv3157nuoM0.999
Rv3152nuoH0.999
Rv3147nuoC0.999
Rv3158nuoN0.999
Rv1308atpA0.904
Rv1308atpA0.904
Rv1308atpA0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
reduced nicotinamide adenine dinucleotidePubChem0.967665.441
NAD+PubChem0.927663.425
CoQPubChem0.916318.407
ubiquinonesPubChem0.907250.29
ubiquinol-1PubChem0.9252.306
ubiquinolPubChem0.9320.423
dihydronicotinamide formycin dinucleotidePubChem0.9665.441