Rv3150

Tuberculist information
Gene namenuoF
Protein functionProbable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3515.41
Molecular mass(da)48101.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 445
	  		  	1    MTTQATPLTPVISRHWDDPESWTLATYQRHDRYRGYQALQKALTMPPDDVISIVKDSGLR   60
			  	61   GRGGAGFATGTKWSFIPQGDTGAAAKPHYLVVNADESEPGTCKDIPLMLATPHVLIEGVI  120
			  	121  IAAYAIRAHHAFVYVRGEVVPVLRRLHNAVAEAYAAGFLGRNIGGSGFDLELVVHAGAGA  180
			  	181  YICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILGGIDWFR  240
			  	241  SMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLKFWTPGGSSTP  300
			  	301  LLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDETTCVVRAVRRWTEFYKHESCGKCTPCR  360
			  	361  EGTFWLDKIYERLETGRGSHEDIDKLLDISDSILGKSFCALGDGAASPVMSSIKHFRDEY  420
			  	421  LAHVEGGGCPFDPRDSMLVANGVDA

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 54 to 230  |  Coverage: 39% Complex1_51K Range: 252 to 302  |  Coverage: 11% SLBB Range: 338 to 383  |  Coverage: 10% NADH_4Fe-4S Range: 11 to 438  |  Coverage: 95% 1 Range: 2 to 437  |  Coverage: 97% 1 Range: 2 to 250  |  Coverage: 55% 2 Range: 334 to 437  |  Coverage: 23% 3 Range: 251 to 333  |  Coverage: 18% 4
Number of amino acids : 445
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Complex1_51KPF0151254-230
SLBBPF10531252-302
NADH_4Fe-4SPF10589338-383
Mtb Structural Proteome models
Model Number1
Model nameRv3150
Template2FUG    1PDBCREDO
Template coverage16_437
Template Identity(%)51.7
Model coverage(%)96.0
Normalized DOPE score-0.63

Structure Models from Chopin
Model Number1
Profilea.29.12.1, c.142.1.1, d.15.13.1
Click for model details
zscore79.53
Residue begin2
Residue end437
Model Number2
Profilec.142.1.1
Click for model details
zscore56.66
Residue begin2
Residue end250
Model Number3
Profilea.29.12.1
Click for model details
zscore26.23
Residue begin334
Residue end437
Model Number4
Profiled.15.13.1
Click for model details
zscore19.19
Residue begin251
Residue end333
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3150Gene nameConfidence Score
Rv3155nuoK0.999
Rv3151nuoG0.999
Rv3145nuoA0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3146nuoB0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3147nuoC0.999
Rv3157nuoM0.999
Rv3152nuoH0.999
Rv3148nuoD0.999
Rv3158nuoN0.999
Rv3153nuoI0.999
Rv3149nuoE0.999
Rv3154nuoJ0.999
Rv3151nuoG0.999
Rv0952sucD0.948
Rv0952sucD0.948
Rv1308atpA0.932
Rv1308atpA0.932
Rv1308atpA0.932
Rv1310atpD0.904
Rv1310atpD0.904
Rv1310atpD0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
reduced nicotinamide adenine dinucleotidePubChem0.979665.441
NAD+PubChem0.951663.425
ubiquinonesPubChem0.938250.29
CoQPubChem0.912318.407
ubiquinol-1PubChem0.9252.306
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
ubiquinolPubChem0.9320.423
flavin mononucleotidePubChem0.791456.344
calciumPubChem0.70940.078
magnesiumPubChem0.70324.305
manganesePubChem0.70354.938