Rv3145

Tuberculist information
Gene namenuoA
Protein functionProbable NADH dehydrogenase I (chain A) NuoA (NADH-ubiquinone oxidoreductase chain A)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3511.68
Molecular mass(da)13957.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 128
	  		  	1    LNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGIEPASTGARTSIGPGA   60
			  	61   ASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFALVEMAIFMLTVFVAYAYVW  120
			  	121  RRGGLTWD

Known structures in the PDB
No Known structures
1 13 25 37 49 61 73 85 97 109 121 Range: 16 to 127  |  Coverage: 86% Oxidored_q4
Number of amino acids : 128
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Oxidored_q4PF0050716-127
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
Structure models not available for this query
STRING
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Protein interacting with Rv3145Gene nameConfidence Score
Rv3150nuoF0.999
Rv3158nuoN0.999
Rv3153nuoI0.999
Rv3150nuoF0.999
Rv3146nuoB0.999
Rv3154nuoJ0.999
Rv3151nuoG0.999
Rv3147nuoC0.999
Rv3155nuoK0.999
Rv3151nuoG0.999
Rv3148nuoD0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3149nuoE0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3150nuoF0.999
Rv3157nuoM0.999
Rv3152nuoH0.999
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.924663.425
ubiquinol-1PubChem0.9252.306
ubiquinolPubChem0.9320.423
CoQPubChem0.9318.407
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
ubiquinonesPubChem0.9250.29