Rv3146

Tuberculist information
Gene namenuoB
Protein functionProbable NADH dehydrogenase I (chain B) NuoB (NADH-ubiquinone oxidoreductase chain B)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3512.08
Molecular mass(da)20186.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 184
	  		  	1    VGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMATAGPRFDIARFGMERF   60
			  	61   SATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCASSGGMFNNYAIVQGVD  120
			  	121  HVVPVDIYLPGCPPRPEMLLHAILKLHEKIQQMPLGINRERAIAEAEEAALLARPTIEMR  180
			  	181  GLLR

Known structures in the PDB
No Known structures
1 19 37 55 73 91 109 127 145 163 181 Range: 36 to 146  |  Coverage: 59% Oxidored_q6 Range: 10 to 161  |  Coverage: 82% 1 Range: 7 to 167  |  Coverage: 86% 1
Number of amino acids : 184
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Oxidored_q6PF0105836-146
Mtb Structural Proteome models
Model Number1
Model nameRv3146
Template2FUG    6PDBCREDO
Template coverage18_169
Template Identity(%)65.2
Model coverage(%)82.1
Normalized DOPE score0.344

Structure Models from Chopin
Model Number1
Profilee.19.1.2
Click for model details
zscore33.38
Residue begin7
Residue end167
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3146Gene nameConfidence Score
Rv3150nuoF0.999
Rv3153nuoI0.999
Rv3150nuoF0.999
Rv3145nuoA0.999
Rv3151nuoG0.999
Rv3147nuoC0.999
Rv3155nuoK0.999
Rv3151nuoG0.999
Rv3148nuoD0.999
Rv3151nuoG0.999
Rv3149nuoE0.999
Rv3151nuoG0.999
Rv3150nuoF0.999
Rv3152nuoH0.999
Rv3156nuoL0.998
Rv3156nuoL0.998
Rv3157nuoM0.998
Rv3158nuoN0.997
Rv3154nuoJ0.996
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
reduced nicotinamide adenine dinucleotidePubChem0.966665.441
NAD+PubChem0.951663.425
ubiquinonesPubChem0.913250.29
CoQPubChem0.912318.407
ubiquinol-1PubChem0.9252.306
ubiquinolPubChem0.9320.423
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
flavin mononucleotidePubChem0.828456.344
4Fe-4SPubChem0.78988.9179
rotenonePubChem0.736394.417