Rv3157

Tuberculist information
Gene namenuoM
Protein functionProbable NADH dehydrogenase I (chain M) NUOK (NADH-ubiquinone oxidoreductase chain M)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3524.13
Molecular mass(da)59175.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 553
	  		  	1    VNNVPWLSVLWLVPLAGAVLIILLPPGRRRLAKWAGMVVSVLTLAVSIVVAAEFKPSAEP   60
			  	61   YQFVEKHSWIPAFGAGYTLGVDGIAVVLVLLTTVLIPLLLVAGWNDATDADDLSPASGRY  120
			  	121  PQRPAPPRLRSSGGERTRGVHAYVALTLAIESMVLMSVIALDVLLFYVFFEAMLIPMYFL  180
			  	181  IGGFGQGAGRSRAAVKFLLYNLFGGLIMLAAVIGLYVVTAQYDSGTFDFREIVAGVAAGR  240
			  	241  YGADPAVFKALFLGFMFAFAIKAPLWPFHRWLPDAAVESTPATAVLMMAVMDKVGTFGML  300
			  	301  RYCLQLFPDPSTYFRPLIVTLAIIGVIYGAIVAIGQTDMMRLIAYTSISHFGFIIAGIFV  360
			  	361  MTTQGQSGSTLYMLNHGLSTAAVFLIAGFLIARRGSRSIADYGGVQKVAPILAGTFMVSA  420
			  	421  MATVSLPGLAPFISEFLVLLGTFSRYWLAAAFGVTALVLSAVYMLWLYQRVMTGPVAEGN  480
			  	481  ERIGDLVGREMIVVAPLIALLLVLGVYPKPVLDIINPAVENTMTTIGQHDPAPSVAHPVP  540
			  	541  AVGASRTAEGPHP

Known structures in the PDB
No Known structures
1 56 111 166 221 276 331 386 441 496 551 Range: 142 to 442  |  Coverage: 54% Oxidored_q1 Range: 141 to 514  |  Coverage: 67% 1
Number of amino acids : 553
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Oxidored_q1PF00361142-442
Mtb Structural Proteome models
Model Number1
Model nameRv3157
Template1V54    APDBCREDO
Template coverage61_433
Template Identity(%)13.7
Model coverage(%)67.5
Normalized DOPE score0.894

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3157Gene nameConfidence Score
Rv3150nuoF0.999
Rv3158nuoN0.999
Rv3152nuoH0.999
Rv3150nuoF0.999
Rv3145nuoA0.999
Rv3153nuoI0.999
Rv3150nuoF0.999
Rv3154nuoJ0.999
Rv3151nuoG0.999
Rv3147nuoC0.999
Rv3155nuoK0.999
Rv3151nuoG0.999
Rv3148nuoD0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3149nuoE0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3146nuoB0.998
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
reduced nicotinamide adenine dinucleotidePubChem0.932665.441
ubiquinonesPubChem0.918250.29
ubiquinolPubChem0.905320.423
CoQPubChem0.905318.407
ubiquinol-1PubChem0.9252.306
NAD+PubChem0.9663.425
dihydronicotinamide formycin dinucleotidePubChem0.9665.441