Rv3149

Tuberculist information
Gene namenuoE
Protein functionProbable NADH dehydrogenase I (chain E) NuoE (NADH-ubiquinone oxidoreductase chain E)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3514.66
Molecular mass(da)27165.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 252
	  		  	1    VTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAKEIIGRYPDRRSALLP   60
			  	61   LLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYRRRPTGEYLVGVCTNTLCA  120
			  	121  VMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACDYAPVVMVNWEFFDNQTPESA  180
			  	181  RELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEGQGGPGAPTLAGLQVARKN  240
			  	241  DMQAPPTPGADE

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 44 to 188  |  Coverage: 57% Complex1_24kDa Range: 38 to 195  |  Coverage: 62% 1 Range: 36 to 252  |  Coverage: 85% 1
Number of amino acids : 252
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Complex1_24kDaPF0125744-188
Mtb Structural Proteome models
Model Number1
Model nameRv3149
Template2FUG    2PDBCREDO
Template coverage5_165
Template Identity(%)34.2
Model coverage(%)62.3
Normalized DOPE score-0.463

Structure Models from Chopin
Model Number1
Profilec.47.1.21
Click for model details
zscore39.75
Residue begin36
Residue end252
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3149Gene nameConfidence Score
Rv3151nuoG0.999
Rv3148nuoD0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3150nuoF0.999
Rv3157nuoM0.999
Rv3152nuoH0.999
Rv3150nuoF0.999
Rv3153nuoI0.999
Rv3150nuoF0.999
Rv3145nuoA0.999
Rv3151nuoG0.999
Rv3146nuoB0.999
Rv3155nuoK0.999
Rv3151nuoG0.999
Rv3147nuoC0.999
Rv3156nuoL0.999
Rv3158nuoN0.998
Rv3154nuoJ0.998
Rv1308atpA0.905
Rv1308atpA0.905
Rv1308atpA0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
reduced nicotinamide adenine dinucleotidePubChem0.963665.441
NAD+PubChem0.934663.425
CoQPubChem0.914318.407
ubiquinol-1PubChem0.9252.306
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
ubiquinolPubChem0.9320.423
ubiquinonesPubChem0.9250.29
flavin mononucleotidePubChem0.809456.344