Tuberculist information
Gene namenuoN
Protein functionProbable NADH dehydrogenase I (chain N) NuoN (NADH-ubiquinone oxidoreductase chain N)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3525.79
Molecular mass(da)55342.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 531
	  		  	1    MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVV   60
			  	61   ARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARL  120
			  	121  PGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSVGGMMVFPASNDLLTMFVALE  180
			  	181  VLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDA  240
			  	241  LAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGA  300
			  	301  LLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGV  360
			  	361  IADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAGSEDADLSHWAGLGQRSPIVG  420
			  	421  VMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMF  480
			  	481  FTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Oxidored_q1PF00361169-449
Mtb Structural Proteome models
Model Number1
Model nameRv3158
Template1V54    APDBCREDO
Template coverage7_367
Template Identity(%)11.5
Model coverage(%)58.6
Normalized DOPE score0.999

Model Number2
Model nameRv3158.2
Template1FFT    APDBCREDO
Template coverage189_487
Template Identity(%)8.7
Model coverage(%)58.8
Normalized DOPE score1.581

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3158Gene nameConfidence Score
Rv3151nuoG0.999
Rv3150nuoF0.999
Rv3157nuoM0.999
Rv3152nuoH0.999
Rv3150nuoF0.999
Rv3145nuoA0.999
Rv3153nuoI0.999
Rv3150nuoF0.999
Rv3154nuoJ0.999
Rv3151nuoG0.999
Rv3147nuoC0.999
Rv3155nuoK0.999
Rv3151nuoG0.999
Rv3148nuoD0.999
Rv3156nuoL0.999
Rv3151nuoG0.999
Rv3156nuoL0.999
Rv3149nuoE0.998
Rv3146nuoB0.997
Rv0082Rv00820.909
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv3158.211xkk_FMM_A_91PDBCREDO0.7520.0470.6580.001
Rv3158.211sa1_POD_B_700PDBCREDO0.7590.0430.6580.001
Rv3158.211sa1_POD_D_701PDBCREDO0.7620.0410.6410.001
Rv3158.253ln1_CEL_D_682PDBCREDO0.6610.1140.6390.001
Rv3158.213e22_LOC_D_700PDBCREDO0.8240.0170.6320.001
Rv3158.213e22_LOC_B_700PDBCREDO0.8210.0180.6300.001
Rv3158.213sm2_478_A_126PDBCREDO0.7500.0480.6240.001
Rv3158.253h0a_9RA_A_500PDBCREDO0.6380.1370.6160.002
Rv3158.251fm6_BRL_D_503PDBCREDO0.6350.1390.6130.002
Rv3158.213h52_486_B_1PDBCREDO0.7250.0630.6100.002
Rv3158.252h77_T3_A_1PDBCREDO0.6520.1230.6080.002
Rv3158.253qt0_486_A_4PDBCREDO0.6290.1460.6080.002
Rv3158.213frq_ERY_A_195PDBCREDO0.6800.0970.6070.002
Rv3158.213b0w_DGX_B_1PDBCREDO0.6240.1520.6070.002
Rv3158.253jwq_VIA_D_901PDBCREDO0.6260.1490.6050.002
Rv3158.252prg_BRL_A_1PDBCREDO0.6250.1510.6030.002
Rv3158.253oct_1N1_A_663PDBCREDO0.6030.1750.6030.002
Rv3158.252h42_VIA_C_903PDBCREDO0.6420.1320.5980.002
Rv3158.213h52_486_A_3PDBCREDO0.7330.0580.5980.002
Rv3158.251bsx_T3_A_1PDBCREDO0.6840.0940.5980.002
Rv3158.251bsx_T3_B_2PDBCREDO0.6840.0940.5980.002
Rv3158.213h52_486_D_2PDBCREDO0.7320.0590.5970.002
Rv3158.253nrr_D16_B_520PDBCREDO0.5970.1820.5970.002
Rv3158.252h79_T3_A_1PDBCREDO0.6590.1150.5960.002
Rv3158.211n49_RIT_B_301PDBCREDO0.5950.1850.5950.002
Rv3158.212qxs_RAL_A_600PDBCREDO0.6110.1650.5950.002
Rv3158.212qxs_RAL_B_600PDBCREDO0.6110.1660.5940.002
Rv3158.253ln1_CEL_A_682PDBCREDO0.6780.0990.5930.002
Rv3158.253ln1_CEL_B_682PDBCREDO0.6780.0990.5930.002
Rv3158.253gws_T3_X_500PDBCREDO0.6780.0990.5920.002
Rv3158.252prg_BRL_B_2PDBCREDO0.6130.1630.5920.002
Rv3158.211n49_RIT_D_401PDBCREDO0.6440.1300.5920.002
Rv3158.251s9p_DES_A_459PDBCREDO0.6120.1650.5910.002
Rv3158.251zgy_BRL_A_503PDBCREDO0.6330.1420.5910.002
Rv3158.253ln1_CEL_C_682PDBCREDO0.6750.1010.5900.003
Rv3158.252cbr_A80_A_201PDBCREDO0.6780.0990.5870.003
Rv3158.213bjw_SVR_E_503PDBCREDO0.6190.1570.5860.003
Rv3158.251gs4_ZK5_A_1918PDBCREDO0.6290.1460.5860.003
Rv3158.253jwq_VIA_B_901PDBCREDO0.6290.1460.5860.003
Rv3158.211t46_STI_A_3PDBCREDO0.6340.1410.5840.003
Rv3158.252q1v_PDN_A_248PDBCREDO0.5840.1990.5840.003
Rv3158.253uvv_T3_A_501PDBCREDO0.6890.0890.5830.003
Rv3158.213gp0_NIL_A_1PDBCREDO0.6480.1260.5820.003
Rv3158.251xzx_T3_X_500PDBCREDO0.6860.0920.5810.003
Rv3158.213spk_TPV_B_100PDBCREDO0.6500.1250.5800.003
Rv3158.254eb6_VLB_C_503PDBCREDO0.6220.1540.5800.003
Rv3158.213cs9_NIL_A_600PDBCREDO0.5780.2060.5780.003
Rv3158.253ads_IMN_A_2PDBCREDO0.5780.2060.5780.003
Rv3158.252h42_VIA_B_902PDBCREDO0.6180.1590.5750.003
Rv3158.252h42_VIA_A_901PDBCREDO0.5950.1850.5750.003
Rv3158.251ya3_STR_A_1001PDBCREDO0.5740.2110.5740.003
Rv3158.253h52_486_C_4PDBCREDO0.6160.1610.5740.003
Rv3158.251ya3_STR_B_2001PDBCREDO0.5720.2140.5720.003
Rv3158.251p93_DEX_B_2999PDBCREDO0.5900.1910.5700.004
Rv3158.251p93_DEX_A_1999PDBCREDO0.5880.1940.5680.004
Rv3158.251nhz_486_A_800PDBCREDO0.6080.1700.5680.004
Rv3158.251sqn_NDR_A_1001PDBCREDO0.5870.1950.5670.004
Rv3158.213ufn_ROC_A_401PDBCREDO0.6290.1460.5650.004
Rv3158.251fm6_BRL_X_504PDBCREDO0.6670.1080.5650.004
Rv3158.251sqn_NDR_B_2001PDBCREDO0.5850.1980.5640.004
Rv3158.252x9g_LYA_D_1270PDBCREDO0.5640.2240.5640.004
Rv3158.252x9g_LYA_C_1270PDBCREDO0.5640.2250.5640.004
Rv3158.251a28_STR_A_1PDBCREDO0.5830.2000.5630.004
Rv3158.252xkw_P1B_B_1475PDBCREDO0.6040.1740.5630.004
Rv3158.253aod_RFP_C_2002PDBCREDO0.6260.1500.5620.004
Rv3158.212oax_SNL_F_6001PDBCREDO0.6670.1090.5610.004
Rv3158.212xkw_P1B_A_1478PDBCREDO0.6580.1170.5610.004
Rv3158.252gqg_1N1_A_501PDBCREDO0.6020.1770.5610.004
Rv3158.212oax_SNL_E_5001PDBCREDO0.6660.1090.5610.004
Rv3158.253k2h_LYA_B_514PDBCREDO0.5800.2040.5600.004
Rv3158.212oax_SNL_A_1001PDBCREDO0.6650.1100.5590.004
Rv3158.212oax_SNL_D_4001PDBCREDO0.6640.1110.5590.004
Rv3158.213cs9_NIL_B_600PDBCREDO0.5730.2120.5580.004
Rv3158.213frq_ERY_B_195PDBCREDO0.7270.0620.5570.004
Rv3158.253erd_DES_A_600PDBCREDO0.5970.1820.5570.004
Rv3158.213ut5_LOC_B_502PDBCREDO0.6810.0960.5560.005
Rv3158.253k54_1N1_A_1PDBCREDO0.6180.1580.5550.005
Rv3158.251s9p_DES_D_600PDBCREDO0.5750.2110.5550.005
Rv3158.251y0x_T44_X_500PDBCREDO0.7190.0670.5540.005
Rv3158.252hw2_RFP_A_1200PDBCREDO0.6710.1050.5500.005
Rv3158.212hw2_RFP_A_1200PDBCREDO0.7170.0690.5500.005
Rv3158.253bbt_FMM_D_91PDBCREDO0.5690.2190.5490.005
Rv3158.211uwj_BAX_A_1723PDBCREDO0.5800.2030.5490.005
Rv3158.252x9g_LYA_B_1270PDBCREDO0.5870.1950.5480.005
Rv3158.213ut5_LOC_D_502PDBCREDO0.7140.0700.5480.005
Rv3158.253o1c_ADN_A_127PDBCREDO0.6090.1680.5470.005
Rv3158.251cil_ETS_A_263PDBCREDO0.5660.2230.5460.005
Rv3158.211ya4_CTX_A_1PDBCREDO0.7060.0760.5450.005
Rv3158.252aa6_STR_B_402PDBCREDO0.6040.1750.5450.005
Rv3158.253qgz_ADN_A_127PDBCREDO0.6060.1720.5440.005
Rv3158.252aa6_STR_A_401PDBCREDO0.6030.1760.5440.005
Rv3158.213kk6_CEL_B_1701PDBCREDO0.5590.2320.5440.006
Rv3158.251mx1_THA_C_3PDBCREDO0.5630.2270.5430.006
Rv3158.253adx_IMN_A_2PDBCREDO0.5830.2000.5430.006
Rv3158.252aax_PDN_A_502PDBCREDO0.6010.1780.5430.006
Rv3158.251qkn_RAL_A_600PDBCREDO0.6210.1550.5430.006
Rv3158.213bjw_SVR_H_504PDBCREDO0.6190.1560.5420.006
Rv3158.252aax_PDN_B_503PDBCREDO0.6000.1790.5420.006
Rv3158.213bjw_SVR_B_501PDBCREDO0.6190.1570.5410.006
Rv3158.251ya3_STR_C_3001PDBCREDO0.6030.1760.5410.006
Rv3158.213kk6_CEL_A_701PDBCREDO0.6180.1580.5410.006
Rv3158.251lhu_EST_A_301PDBCREDO0.5600.2300.5410.006
Rv3158.213gcs_BAX_A_401PDBCREDO0.6240.1520.5410.006
Rv3158.213bjw_SVR_F_502PDBCREDO0.6180.1590.5400.006
Rv3158.212q64_1UN_B_1001PDBCREDO0.6660.1090.5400.006
Rv3158.213heg_BAX_A_1PDBCREDO0.6420.1320.5400.006
Rv3158.253oht_1N1_B_1000PDBCREDO0.5600.2310.5400.006
Rv3158.253d90_NOG_A_1001PDBCREDO0.5780.2060.5400.006
Rv3158.254eyb_0WO_A_303PDBCREDO0.5590.2320.5400.006
Rv3158.252fum_MIX_D_3539PDBCREDO0.5580.2330.5390.006
Rv3158.212qak_1UN_A_1001PDBCREDO0.6640.1110.5390.006
Rv3158.213b0w_DGX_A_1PDBCREDO0.6200.1560.5370.006
Rv3158.253vn2_TLS_A_501PDBCREDO0.6760.1010.5370.006
Rv3158.252aa5_STR_A_301PDBCREDO0.5940.1860.5370.006
Rv3158.251uwh_BAX_A_1723PDBCREDO0.6950.0850.5360.006
Rv3158.251uwh_BAX_B_1723PDBCREDO0.6940.0850.5350.006
Rv3158.253d90_NOG_B_2001PDBCREDO0.5730.2130.5350.006
Rv3158.212pym_1UN_A_1001PDBCREDO0.6580.1160.5340.006
Rv3158.252gqg_1N1_B_502PDBCREDO0.5910.1900.5340.006
Rv3158.213cs9_NIL_D_600PDBCREDO0.5790.2050.5340.007
Rv3158.212pyn_1UN_A_1001PDBCREDO0.6580.1170.5340.007
Rv3158.252x9g_LYA_A_1270PDBCREDO0.6300.1450.5330.007
Rv3158.212q63_1UN_A_1001PDBCREDO0.6560.1180.5320.007
Rv3158.251a27_EST_A_350PDBCREDO0.6640.1110.5320.007
Rv3158.211skx_RFP_A_1PDBCREDO0.5460.2490.5320.007
Rv3158.213lzv_017_A_200PDBCREDO0.5460.2500.5310.007
Rv3158.251uob_PNN_A_1311PDBCREDO0.7100.0740.5310.007
Rv3158.253kw2_ADN_A_300PDBCREDO0.6110.1660.5290.007
Rv3158.211y0x_T44_X_500PDBCREDO0.6480.1270.5290.007
Rv3158.251p93_DEX_D_4999PDBCREDO0.6040.1740.5280.007
Rv3158.251p93_DEX_C_3999PDBCREDO0.6030.1750.5270.007
Rv3158.213cs9_NIL_C_600PDBCREDO0.5720.2150.5270.007
Rv3158.251kij_NOV_A_400PDBCREDO0.5440.2520.5260.007
Rv3158.251uwj_BAX_B_1723PDBCREDO0.7250.0630.5260.007
Rv3158.252aa5_STR_B_302PDBCREDO0.5820.2010.5260.007
Rv3158.251m2z_DEX_A_301PDBCREDO0.6000.1790.5250.007
Rv3158.253mne_DEX_A_784PDBCREDO0.6000.1800.5240.008
Rv3158.211xzx_T3_X_500PDBCREDO0.7050.0770.5240.008
Rv3158.251m2z_DEX_D_401PDBCREDO0.5990.1800.5240.008
Rv3158.251lhv_NOG_A_301PDBCREDO0.6180.1580.5230.008
Rv3158.253oht_1N1_A_1000PDBCREDO0.6040.1740.5230.008
Rv3158.253gn8_DEX_B_247PDBCREDO0.5980.1820.5220.008
Rv3158.213el0_1UN_A_201PDBCREDO0.5370.2620.5220.008
Rv3158.253gn8_DEX_A_247PDBCREDO0.5960.1830.5210.008
Rv3158.211opj_STI_B_4PDBCREDO0.5210.2860.5210.008
Rv3158.213uvv_T3_A_501PDBCREDO0.7010.0800.5210.008
Rv3158.251a28_STR_B_2PDBCREDO0.6150.1620.5200.008
Rv3158.211opj_STI_A_3PDBCREDO0.5190.2880.5190.008
Rv3158.213bbt_FMM_D_91PDBCREDO0.7970.0260.5190.008
Rv3158.214asd_BAX_A_1500PDBCREDO0.5980.1810.5190.008
Rv3158.253sxr_1N1_A_1PDBCREDO0.6710.1040.5180.008
Rv3158.213mnp_DEX_A_784PDBCREDO0.6530.1210.5170.008
Rv3158.252uxo_TAC_B_1211PDBCREDO0.6960.0840.5160.009
Rv3158.253bbt_FMM_B_91PDBCREDO0.6180.1580.5150.009
Rv3158.213mno_DEX_A_784PDBCREDO0.6510.1230.5150.009
Rv3158.253k2h_LYA_A_514PDBCREDO0.6420.1330.5150.009
Rv3158.212nni_MTK_A_501PDBCREDO0.5760.2090.5140.009
Rv3158.213vhu_SNL_A_1001PDBCREDO0.6680.1070.5130.009
Rv3158.212ab2_SNL_A_502PDBCREDO0.6680.1080.5120.009
Rv3158.212ab2_SNL_B_503PDBCREDO0.6680.1080.5120.009
Rv3158.213ogq_AB1_A_200PDBCREDO0.6000.1790.5120.009
Rv3158.212oax_SNL_B_2001PDBCREDO0.6660.1090.5110.009
Rv3158.251uwj_BAX_A_1723PDBCREDO0.7680.0380.5110.009
Rv3158.251z2b_VLB_C_800PDBCREDO0.6830.0940.5110.009
Rv3158.253erd_DES_B_800PDBCREDO0.5470.2480.5100.009
Rv3158.253kw2_ADN_B_300PDBCREDO0.6610.1140.5100.009
Rv3158.211z2b_VLB_C_800PDBCREDO0.6050.1730.5090.009
Rv3158.212oax_SNL_C_3001PDBCREDO0.6630.1120.5090.010
Rv3158.211fm6_BRL_X_504PDBCREDO0.6830.0940.5080.010
Rv3158.211c6y_MK1_B_524PDBCREDO0.5350.2650.5070.010
Rv3158.252fum_MIX_A_539PDBCREDO0.5440.2520.5070.010
Rv3158.251mx1_THA_E_5PDBCREDO0.5640.2250.5060.010
Rv3158.253frq_ERY_B_195PDBCREDO0.6170.1590.5060.010
Rv3158.253o1x_ADN_A_1450PDBCREDO0.5430.2540.5060.010
Rv3158.254eyb_0WO_B_301PDBCREDO0.5630.2260.5060.010
Rv3158.252xpv_MIY_A_1209PDBCREDO0.5220.2850.5040.010
Rv3158.213gws_T3_X_500PDBCREDO0.7000.0810.5040.010
Rv3158.252ab2_SNL_A_502PDBCREDO0.6140.1630.5030.010
Rv3158.211bsx_T3_A_1PDBCREDO0.6990.0810.5030.010
Rv3158.211bsx_T3_B_2PDBCREDO0.6990.0810.5030.010
Rv3158.251s9p_DES_B_459PDBCREDO0.6520.1230.5030.010
Rv3158.211uwj_BAX_B_1723PDBCREDO0.5790.2050.5020.011
Rv3158.212oiq_STI_A_1001PDBCREDO0.5970.1830.5020.011
Rv3158.252ab2_SNL_B_503PDBCREDO0.6110.1660.5010.011
Rv3158.253sxr_1N1_B_2PDBCREDO0.6760.1000.5010.011
Rv3158.213so9_017_A_100PDBCREDO0.6140.1630.5010.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.901663.425
ubiquinol-1PubChem0.9252.306
ubiquinolPubChem0.9320.423
CoQPubChem0.9318.407
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
ubiquinonesPubChem0.9250.29