SInCRe - Rv3152

Tuberculist information

Gene name	nuoH
Protein function	Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3519.28
Molecular mass(da)	44657.6
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 410

	  		  	1    MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLA   60
			  	61   DGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLP  120
			  	121  VAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSFATVFLMAGT  180
			  	181  MSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLK  240
			  	241  FAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIY  300
			  	301  FWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVA  360
			  	361  AAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLLAGATKENAGG

Known structures in the PDB

No Known structures

Number of amino acids : 410

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
NADHdh	PF00146	11-339

Mtb Structural Proteome models

Structure models not available for this query

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

Structure models not available for this query

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3152	Gene name	Confidence Score
Rv3150	nuoF	0.999
Rv3146	nuoB	0.999
Rv3155	nuoK	0.999
Rv3151	nuoG	0.999
Rv3147	nuoC	0.999
Rv3156	nuoL	0.999
Rv3151	nuoG	0.999
Rv3148	nuoD	0.999
Rv3156	nuoL	0.999
Rv3151	nuoG	0.999
Rv3149	nuoE	0.999
Rv3157	nuoM	0.999
Rv3151	nuoG	0.999
Rv3150	nuoF	0.999
Rv3158	nuoN	0.999
Rv3153	nuoI	0.999
Rv3150	nuoF	0.999
Rv3145	nuoA	0.999
Rv3154	nuoJ	0.999
Rv3043c	ctaD	0.935
Rv1308	atpA	0.922
Rv1308	atpA	0.922
Rv1308	atpA	0.922
Rv0086	hycQ	0.904

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
ubiquinonesPubChem	0.945	250.29
CoQPubChem	0.939	318.407
reduced nicotinamide adenine dinucleotidePubChem	0.934	665.441
ubiquinol-1PubChem	0.9	252.306
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
NAD+PubChem	0.9	663.425
ubiquinolPubChem	0.9	320.423
rotenonePubChem	0.765	394.417