Rv1310

Tuberculist information
Gene nameatpD
Protein functionProbable ATP synthase beta chain AtpD
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1465.84
Molecular mass(da)53094.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 486
	  		  	1    MTTTAEKTDRPGKPGSSDTSGRVVRVTGPVVDVEFPRGSIPELFNALHAEITFESLAKTL   60
			  	61   TLEVAQHLGDNLVRTISLQPTDGLVRGVEVIDTGRSISVPVGEGVKGHVFNALGDCLDEP  120
			  	121  GYGEKFEHWSIHRKPPAFEELEPRTEMLETGLKVVDLLTPYVRGGKIALFGGAGVGKTVL  180
			  	181  IQEMINRIARNFGGTSVFAGVGERTREGNDLWVELAEANVLKDTALVFGQMDEPPGTRMR  240
			  	241  VALSALTMAEWFRDEQGQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGE  300
			  	301  LQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDATTELSRAVFSKGIFPAVDPL  360
			  	361  ASSSTILDPSVVGDEHYRVAQEVIRILQRYKDLQDIIAILGIDELSEEDKQLVNRARRIE  420
			  	421  RFLSQNMMAAEQFTGQPGSTVPVKETIEAFDRLCKGDFDHVPEQAFFLIGGLDDLAKKAE  480
			  	481  SLGAKL

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 23 to 94  |  Coverage: 14% ATP-synt_ab_N Range: 150 to 364  |  Coverage: 44% ATP-synt_ab Range: 377 to 485  |  Coverage: 22% ATP-synt_ab_C Range: 19 to 483  |  Coverage: 95% 1 Range: 16 to 485  |  Coverage: 96% 1 Range: 377 to 484  |  Coverage: 22% 2 Range: 12 to 100  |  Coverage: 18% 3
Number of amino acids : 486
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ATP-synt_ab_NPF0287423-94
ATP-synt_abPF00006150-364
ATP-synt_ab_CPF00306377-485
Mtb Structural Proteome models
Model Number1
Model nameRv1310
Template1SKY    EPDBCREDO
Template coverage2_470
Template Identity(%)65.4
Model coverage(%)95.5
Normalized DOPE score-0.816

Structure Models from Chopin
Model Number1
Profile1.10.1140.10, 2.40.10.170, 3.40.50.300
Click for model details
zscore73.36
Residue begin16
Residue end485
Model Number2
Profile1.10.1140.10
Click for model details
zscore26.21
Residue begin377
Residue end484
Model Number3
Profileb.49.1.1
Click for model details
zscore13.42
Residue begin12
Residue end100
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1310Gene nameConfidence Score
Rv1308atpA0.999
Rv1309atpG0.999
Rv1306atpF0.999
Rv1311atpC0.999
Rv1308atpA0.999
Rv1308atpA0.999
Rv1304atpB0.999
Rv1305atpE0.998
Rv1307atpH0.993
Rv1307atpH0.993
Rv3628ppa0.98
Rv0685tuf0.977
Rv0685tuf0.977
Rv0685tuf0.977
Rv3148nuoD0.976
Rv1023eno0.971
Rv1023eno0.971
Rv0733adk0.969
Rv0952sucD0.969
Rv0952sucD0.969
Rv1248cRv1248c0.949
Rv1248cRv1248c0.949
Rv1248cRv1248c0.949
Rv3153nuoI0.937
Rv2889ctsf0.929
Rv2889ctsf0.929
Rv0951sucC0.925
Rv0951sucC0.925
Rv0667rpoB0.919
Rv0667rpoB0.919
Rv0667rpoB0.919
Rv0667rpoB0.919
Rv0667rpoB0.919
Rv0667rpoB0.919
Rv0704rplB0.917
Rv0704rplB0.917
Rv1112Rv11120.916
Rv1112Rv11120.916
Rv0684fusA10.909
Rv0684fusA10.909
Rv0684fusA10.909
Rv0684fusA10.909
Rv0684fusA10.909
Rv3150nuoF0.904
Rv3150nuoF0.904
Rv3150nuoF0.904
Rv2215dlaT0.903
Rv2215dlaT0.903
Rv2215dlaT0.903
Rv0440groEL20.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.98396.9872
adenosine triphosphatePubChem0.982507.181
adenosine diphosphatePubChem0.979427.201
deuteriumPubChem0.9592.01588
H(+)PubChem0.9552.01588
adenosine monophosphatePubChem0.9347.221
deoxyadenosine triphosphatePubChem0.9491.182
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
magnesiumPubChem0.82324.305
hydron diphosphatePubChem0.797391.981
AMPPNPPubChem0.783506.196
glycerolPubChem0.76992.0938
BAAPubChem0.743191.269
quercetinPubChem0.733302.236
EGCGPubChem0.723458.372
dicyclohexylcarbodiimidePubChem0.718206.327
azidePubChem0.71742.0201
resveratrolPubChem0.703228.243
piceatannolPubChem0.703244.243