Rv1307

Tuberculist information
Gene nameatpH
Protein functionProbable ATP synthase delta chain AtpH
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1461.84
Molecular mass(da)48805.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 446
	  		  	1    MSTFIGQLFGFAVIVYLVWRFIVPLVGRLMSARQDTVRQQLADAAAAADRLAEASQAHTK   60
			  	61   ALEDAKSEAHRVVEEARTDAERIAEQLEAQADVEAERIKMQGARQVDLIRAQLTRQLRLE  120
			  	121  LGHESVRQARELVRNHVADQAQQSATVDRFLDQLDAMAPATADVDYPLLAKMRSASRRAL  180
			  	181  TSLVDWFGTMAQDLDHQGLTTLAGELVSVARLLDREAVVTRYLTVPAEDATPRIRLIERL  240
			  	241  VSGKVGAPTLEVLRTAVSKRWSANSDLIDAIEHVSRQALLELAERAGQVDEVEDQLFRFS  300
			  	301  RILDVQPRLAILLGDCAVPAEGRVRLLRKVLERADSTVNPVVVALLSHTVELLRGQAVEE  360
			  	361  AVLFLAEVAVARRGEIVAQVGAAAELSDAQRTRLTEVLSRIYGHPVTVQLHIDAALLGGL  420
			  	421  SIAVGDEVIDGTLSSRLAAAEARLPD

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 3 to 134  |  Coverage: 29% ATP-synt_B Range: 274 to 444  |  Coverage: 38% OSCP Range: 270 to 370  |  Coverage: 22% 1 Range: 58 to 118  |  Coverage: 13% 1 Range: 274 to 444  |  Coverage: 38% 2
Number of amino acids : 446
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ATP-synt_BPF004303-134
OSCPPF00213274-444
Mtb Structural Proteome models
Model Number1
Model nameRv1307
Template2A7U    BPDBCREDO
Template coverage5_100
Template Identity(%)15.6
Model coverage(%)22.4
Normalized DOPE score-0.584

Structure Models from Chopin
Model Number1
Profilef.23.21.1 - 1.20.5.620
Click for model details
zscore9.72
Residue begin58
Residue end118
Model Number2
Profilec.108.1.4
Click for model details
zscore4.36
Residue begin274
Residue end444
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1307Gene nameConfidence Score
Rv1309atpG0.998
Rv1308atpA0.996
Rv1308atpA0.996
Rv1308atpA0.996
Rv1304atpB0.993
Rv1310atpD0.993
Rv1310atpD0.993
Rv1310atpD0.993
Rv1311atpC0.991
Rv1306atpF0.99
Rv1305atpE0.981
Rv0733adk0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphatePubChem0.996.9872
protiumPubChem0.92.01576
adenosine monophosphatePubChem0.9347.221
deoxyadenosine triphosphatePubChem0.9491.182
hydroxyl radicalsPubChem0.917.0073
H(+)PubChem0.92.01588
adenosine diphosphatePubChem0.9427.201
adenosine triphosphatePubChem0.9507.181
deuteriumPubChem0.92.01588