Rv1305

Tuberculist information
Gene nameatpE
Protein functionProbable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1461.05
Molecular mass(da)8055.49
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 81
	  		  	1    MDPTIAAGALIGGGLIMAGGAIGAGIGDGVAGNALISGVARQPEAQGRLFTPFFITVGLV   60
			  	61   EAAYFINLAFMALFVFATPVK

Known structures in the PDB
No Known structures
1 9 17 25 33 41 49 57 65 73 81 Range: 8 to 77  |  Coverage: 85% ATP-synt_C Range: 2 to 80  |  Coverage: 96% 1 Range: 1 to 81  |  Coverage: 98% 1
Number of amino acids : 81
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ATP-synt_CPF001378-77
Mtb Structural Proteome models
Model Number1
Model nameRv1305
Template1YCE    APDBCREDO
Template coverage7_84
Template Identity(%)28.2
Model coverage(%)96.3
Normalized DOPE score0.866

Structure Models from Chopin
Model Number1
Profile1.20.120.610
Click for model details
zscore4.37
Residue begin1
Residue end81
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1305Gene nameConfidence Score
Rv1308atpA0.999
Rv1304atpB0.999
Rv1308atpA0.999
Rv1311atpC0.999
Rv1308atpA0.999
Rv1309atpG0.998
Rv1306atpF0.998
Rv1310atpD0.998
Rv1310atpD0.998
Rv1310atpD0.998
Rv1307atpH0.981
Rv1307atpH0.981
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CDD-1772NoneNoneNone
CDD-1772NoneNoneNone
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
Transthyretin 1RLBPharmMapper9 hydroph + 1 HB + 0 pos/neg + 0 aromLink
Estradiol 17-beta-dehydrogenase 1 1I5RPharmMapper8 hydroph + 8 HB + 0 pos/neg + 0 aromLink
NONE 3GZ9PharmMapper7 hydroph + 1 HB + 1 pos/neg + 0 aromLink
Alpha-tocopherol transfer protein 1R5LPharmMapper11 hydroph + 1 HB + 0 pos/neg + 0 aromLink
Dual specificity mitogen-activated protein kinase kinase 1 1S9JPharmMapper7 hydroph + 2 HB + 0 pos/neg + 0 aromLink
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
H(+)PubChem0.9122.01588
deuteriumPubChem0.9112.01588
adenosine monophosphatePubChem0.9347.221
deoxyadenosine triphosphatePubChem0.9491.182
hydroxyl radicalsPubChem0.917.0073
adenosine diphosphatePubChem0.9427.201
adenosine triphosphatePubChem0.9507.181
phosphatePubChem0.996.9872
protiumPubChem0.92.01576
Coomassie bluePubChem0.8695.584
R207910PubChem0.717555.505