Rv0704

Tuberculist information
Gene namerplB
Protein function50S ribosomal protein L2 RplB
Functional category(tuberculist)information pathways
Gene location(kb)802.528
Molecular mass(da)30576.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 280
	  		  	1    MAIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGRGGRNAHGRITTRHKGGGHKR   60
			  	61   AYRMIDFRRNDKDGVNAKVAHIEYDPNRTARIALLHYLDGEKRYIIAPNGLSQGDVVESG  120
			  	121  ANADIKPGNNLPLRNIPAGTLIHAVELRPGGGAKLARSAGSSIQLLGKEASYASLRMPSG  180
			  	181  EIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPSVRGVVMNPVDHPHGGGEGKT  240
			  	241  SGGRHPVSPWGKPEGRTRNANKSSNKFIVRRRRTGKKHSR

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 42 to 119  |  Coverage: 27% Ribosomal_L2 Range: 125 to 253  |  Coverage: 45% Ribosomal_L2_C Range: 4 to 271  |  Coverage: 95% 1 Range: 126 to 274  |  Coverage: 52% 1 Range: 196 to 276  |  Coverage: 28% 2
Number of amino acids : 280
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_L2PF0018142-119
Ribosomal_L2_CPF03947125-253
Mtb Structural Proteome models
Model Number1
Model nameRv0704
Template1NKW    APDBCREDO
Template coverage4_273
Template Identity(%)61.6
Model coverage(%)95.4
Normalized DOPE score1.617

Structure Models from Chopin
Model Number1
Profileb.34.5.3
Click for model details
zscore26.58
Residue begin126
Residue end274
Model Number2
Profile4.10.950.10
Click for model details
zscore10.27
Residue begin196
Residue end276
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0704Gene nameConfidence Score
Rv0706rplV0.999
Rv0640rplK0.999
Rv0707rpsC0.999
Rv0716rplE0.999
Rv0640rplK0.999
Rv0707rpsC0.999
Rv0701rplC0.999
Rv0716rplE0.999
Rv0708rplP0.999
Rv0702rplD0.999
Rv0703rplW0.999
Rv0705rpsS0.999
Rv0719rplF0.999
Rv0714rplN0.999
Rv0720rplR0.998
Rv0715rplX0.998
Rv0684fusA10.998
Rv0700rpsJ0.998
Rv0684fusA10.998
Rv0684fusA10.998
Rv0641rplA0.998
Rv3443crplM0.998
Rv0684fusA10.998
Rv0723rplO0.998
Rv0652rplL0.998
Rv3459crpsK0.998
Rv3456crplQ0.998
Rv0684fusA10.998
Rv0721rpsE0.997
Rv0721rpsE0.997
Rv3442crpsI0.997
Rv0651rplJ0.997
Rv0709rpmC0.997
Rv0710rpsQ0.997
Rv3460crpsM0.996
Rv0685tuf0.995
Rv3458crpsD0.995
Rv3458crpsD0.995
Rv0718rpsH0.995
Rv0685tuf0.995
Rv0683rpsG0.995
Rv0685tuf0.995
Rv2441crpmA0.994
Rv3457crpoA0.994
Rv3457crpoA0.994
Rv3457crpoA0.994
Rv0722rpmD0.994
Rv1643rplT0.994
Rv2889ctsf0.992
Rv0668rpoC0.992
Rv0667rpoB0.992
Rv2889ctsf0.992
Rv0668rpoC0.992
Rv0667rpoB0.992
Rv0668rpoC0.992
Rv0667rpoB0.992
Rv0668rpoC0.992
Rv0667rpoB0.992
Rv0717rpsN10.992
Rv0667rpoB0.992
Rv0668rpoC0.992
Rv0667rpoB0.992
Rv0682rpsL0.991
Rv2442crplU0.99
Rv2890crpsB0.99
Rv0056rplI0.99
Rv2056crpsN20.99
Rv0056rplI0.99
Rv0732secY0.99
Rv2904crplS0.988
Rv0120cfusA20.983
Rv0120cfusA20.983
Rv0120cfusA20.983
Rv0120cfusA20.983
Rv0120cfusA20.983
Rv2057crpmG10.977
Rv0634BrpmG20.976
Rv0734mapA0.973
Rv2882cfrr0.971
Rv2839cinfB0.97
Rv2839cinfB0.97
Rv2839cinfB0.97
Rv2839cinfB0.97
Rv2916cffh0.967
Rv2916cffh0.967
Rv2916cffh0.967
Rv3461crpmJ0.966
Rv0639nusG0.965
Rv1023eno0.965
Rv1023eno0.965
Rv0639nusG0.965
Rv1298rpmE0.965
Rv0733adk0.964
Rv2861cmapB0.963
Rv1015crplY0.957
Rv1015crplY0.957
Rv2906ctrmD0.956
Rv1699pyrG0.951
Rv1699pyrG0.951
Rv1630rpsA0.949
Rv2785crpsO0.949
Rv1641infC0.943
Rv1641infC0.943
Rv0053rpsF0.942
Rv2058crpmB20.936
Rv3924crpmH0.931
Rv2783cgpsI0.927
Rv0055rpsR10.927
Rv2783cgpsI0.927
Rv2783cgpsI0.927
Rv2783cgpsI0.927
Rv2783cgpsI0.927
Rv2462ctig0.919
Rv2462ctig0.919
Rv2462ctig0.919
Rv1649pheS0.917
Rv1310atpD0.917
Rv1310atpD0.917
Rv1310atpD0.917
Rv1649pheS0.917
Rv3834cserS0.915
Rv3834cserS0.915
Rv0350dnaK0.914
Rv1536ileS0.911
Rv1536ileS0.911
Rv3462cinfA0.91
Rv2841cnusA0.909
Rv2841cnusA0.909
Rv2909crpsP0.905
Rv1308atpA0.902
Rv1308atpA0.902
Rv1308atpA0.902
Rv3455ctruA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
telithromycinPubChem0.826812.004
zincPubChem0.82165.409
magnesiumPubChem0.81424.305
L-phenylalaninePubChem0.806165.189
spiramycinPubChem0.793843.053
puromycinPubChem0.772471.51
lactatePubChem0.73890.0779
(1R,2R,4R,6R,7R,8R,10S,13R,14S)-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-1PubChem0.709812.004
nchembio.341-comp1PubChem0.7081664.89
bryamycinPubChem0.7081664.89
phosphatePubChem0.70296.9872