SInCRe - Rv3462c

Tuberculist information

Gene name	infA
Protein function	Probable translation initiation factor if-1 InfA
Functional category(tuberculist)	information pathways
Gene location(kb)	3880.43
Molecular mass(da)	8488.93
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 73

	  		  	1    MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQHYIRILPEDRVVVELSP   60
			  	61   YDLSRGRIVYRYK

Known structures in the PDB

No Known structures

Number of amino acids : 73

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
eIF-1a	PF01176	6-71

Mtb Structural Proteome models

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3462c	Gene name	Confidence Score
Rv3460c	rpsM	0.992
Rv0716	rplE	0.989
Rv0716	rplE	0.989
Rv0718	rpsH	0.988
Rv0719	rplF	0.988
Rv3443c	rplM	0.985
Rv0682	rpsL	0.984
Rv3459c	rpsK	0.984
Rv0720	rplR	0.983
Rv0708	rplP	0.98
Rv0707	rpsC	0.978
Rv0707	rpsC	0.978
Rv0683	rpsG	0.977
Rv3456c	rplQ	0.976
Rv0714	rplN	0.976
Rv0721	rpsE	0.974
Rv0721	rpsE	0.974
Rv3458c	rpsD	0.973
Rv3458c	rpsD	0.973
Rv0710	rpsQ	0.971
Rv0684	fusA1	0.97
Rv0684	fusA1	0.97
Rv0684	fusA1	0.97
Rv0684	fusA1	0.97
Rv0684	fusA1	0.97
Rv0641	rplA	0.968
Rv0732	secY	0.966
Rv0723	rplO	0.965
Rv0733	adk	0.961
Rv3457c	rpoA	0.961
Rv3457c	rpoA	0.961
Rv3457c	rpoA	0.961
Rv0703	rplW	0.959
Rv0685	tuf	0.958
Rv0685	tuf	0.958
Rv0685	tuf	0.958
Rv0715	rplX	0.958
Rv3461c	rpmJ	0.957
Rv3648c	cspA	0.954
Rv0717	rpsN1	0.953
Rv0702	rplD	0.95
Rv0651	rplJ	0.949
Rv0640	rplK	0.947
Rv0640	rplK	0.947
Rv0700	rpsJ	0.946
Rv2890c	rpsB	0.944
Rv0734	mapA	0.934
Rv0701	rplC	0.934
Rv0709	rpmC	0.932
Rv0722	rpmD	0.923
Rv2909c	rpsP	0.921
Rv2534c	efp	0.918
Rv2889c	tsf	0.918
Rv2889c	tsf	0.918
Rv2534c	efp	0.918
Rv2534c	efp	0.918
Rv2861c	mapB	0.914
Rv0704	rplB	0.91
Rv0704	rplB	0.91
Rv0053	rpsF	0.903
Rv2056c	rpsN2	0.901

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv3462c_3i4o_A	6	2xkw_P1B_B_1475 PDB CREDO	0.570	0.217	0.549	0.005
Rv3462c_3i4o_A	6	3oht_1N1_A_1000 PDB CREDO	0.564	0.225	0.543	0.006
Rv3462c_3i4o_A	6	3oht_1N1_B_1000 PDB CREDO	0.574	0.211	0.534	0.006
Rv3462c_3i4o_A	6	3qlg_1N1_A_601 PDB CREDO	0.594	0.187	0.530	0.007
Rv3462c_3i4o_A	6	3g5d_1N1_B_1 PDB CREDO	0.591	0.190	0.528	0.007
Rv3462c_3i4o_A	6	3qlg_1N1_B_601 PDB CREDO	0.590	0.191	0.527	0.007
Rv3462c_3i4o_A	6	2zva_1N1_A_513 PDB CREDO	0.605	0.173	0.519	0.008
Rv3462c_3i4o_A	6	3g5d_1N1_A_1 PDB CREDO	0.572	0.214	0.511	0.009
Rv3462c_3i4o_A	6	3r9c_ECL_A_452 PDB CREDO	0.673	0.103	0.511	0.009
Rv3462c_3i4o_A	6	3lfa_1N1_A_361 PDB CREDO	0.668	0.107	0.508	0.010
Rv3462c_3i4o_A	6	1jg3_ADN_A_500 PDB CREDO	0.504	0.312	0.504	0.010
Rv3462c_3i4o_A	6	1sn5_T3_C_601 PDB CREDO	0.664	0.111	0.504	0.010
Rv3462c_3i4o_A	6	3hec_STI_A_1 PDB CREDO	0.681	0.096	0.502	0.011
Rv3462c_3i4o_A	6	3erd_DES_B_800 PDB CREDO	0.521	0.287	0.502	0.011
Rv3462c_3i4o_A	6	3k54_1N1_A_1 PDB CREDO	0.500	0.318	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
IF1PubChem	0.886	501.882
Coomassie bluePubChem	0.821	695.584