Rv0721

Tuberculist information
Gene namerpsE
Protein function30S ribosomal protein S5 RpsE
Functional category(tuberculist)information pathways
Gene location(kb)814.328
Molecular mass(da)22888.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 220
	  		  	1    MAEQPAGQAGTTDNRDARGDREGRRRDSGRGSRERDGEKSNYLERVVAINRVSKVVKGGR   60
			  	61   RFSFTALVIVGDGNGMVGVGYGKAKEVPAAIAKGVEEARKSFFRVPLIGGTITHPVQGEA  120
			  	121  AAGVVLLRPASPGTGVIAGGAARAVLECAGVHDILAKSLGSDNAINVVHATVAALKLLQR  180
			  	181  PEEVAARRGLPIEDVAPAGMLKARRKSEALAASVLPDRTI

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 41 to 107  |  Coverage: 30% Ribosomal_S5 Range: 116 to 189  |  Coverage: 33% Ribosomal_S5_C Range: 36 to 179  |  Coverage: 65% 1 Range: 35 to 110  |  Coverage: 34% 1
Number of amino acids : 220
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_S5PF0033341-107
Ribosomal_S5_CPF03719116-189
Mtb Structural Proteome models
Model Number1
Model nameRv0721
Template1PKP    APDBCREDO
Template coverage5_148
Template Identity(%)59.7
Model coverage(%)65.0
Normalized DOPE score-0.771

Structure Models from Chopin
Model Number1
Profiled.50.1.2
Click for model details
zscore14.91
Residue begin35
Residue end110
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0721Gene nameConfidence Score
Rv0707rpsC0.999
Rv0723rplO0.999
Rv3442crpsI0.999
Rv3459crpsK0.999
Rv0718rpsH0.999
Rv3460crpsM0.999
Rv0705rpsS0.999
Rv0719rplF0.999
Rv0700rpsJ0.999
Rv0720rplR0.999
Rv0707rpsC0.999
Rv0722rpmD0.999
Rv0716rplE0.998
Rv3458crpsD0.998
Rv0682rpsL0.998
Rv0716rplE0.998
Rv0652rplL0.998
Rv3458crpsD0.998
Rv0683rpsG0.998
Rv0717rpsN10.998
Rv0710rpsQ0.998
Rv0714rplN0.998
Rv0701rplC0.998
Rv0641rplA0.998
Rv0667rpoB0.997
Rv0667rpoB0.997
Rv0708rplP0.997
Rv0704rplB0.997
Rv2890crpsB0.997
Rv0667rpoB0.997
Rv0704rplB0.997
Rv0667rpoB0.997
Rv0667rpoB0.997
Rv0667rpoB0.997
Rv0702rplD0.997
Rv0685tuf0.996
Rv3443crplM0.996
Rv0685tuf0.996
Rv0685tuf0.996
Rv2056crpsN20.996
Rv0715rplX0.996
Rv0651rplJ0.995
Rv0668rpoC0.995
Rv3456crplQ0.995
Rv0668rpoC0.995
Rv0640rplK0.995
Rv0668rpoC0.995
Rv0640rplK0.995
Rv0668rpoC0.995
Rv0668rpoC0.995
Rv0684fusA10.994
Rv0684fusA10.994
Rv0684fusA10.994
Rv3457crpoA0.994
Rv0684fusA10.994
Rv3457crpoA0.994
Rv0684fusA10.994
Rv3457crpoA0.994
Rv0703rplW0.993
Rv0706rplV0.993
Rv0053rpsF0.992
Rv0732secY0.99
Rv2785crpsO0.988
Rv1641infC0.988
Rv1641infC0.988
Rv0709rpmC0.986
Rv2442crplU0.984
Rv2889ctsf0.981
Rv2889ctsf0.981
Rv1630rpsA0.98
Rv2412rpsT0.979
Rv1023eno0.977
Rv0734mapA0.977
Rv1023eno0.977
Rv2882cfrr0.977
Rv2441crpmA0.977
Rv2909crpsP0.976
Rv2904crplS0.975
Rv2861cmapB0.975
Rv3462cinfA0.974
Rv1643rplT0.972
Rv0639nusG0.968
Rv0639nusG0.968
Rv2839cinfB0.964
Rv2839cinfB0.964
Rv2839cinfB0.964
Rv2839cinfB0.964
Rv0733adk0.963
Rv3100csmpB0.962
Rv0056rplI0.959
Rv0056rplI0.959
Rv1699pyrG0.953
Rv1699pyrG0.953
Rv0055rpsR10.948
Rv2534cefp0.936
Rv2534cefp0.936
Rv2534cefp0.936
Rv1297rho0.93
Rv1297rho0.93
Rv1297rho0.93
Rv0120cfusA20.929
Rv0120cfusA20.929
Rv0120cfusA20.929
Rv0120cfusA20.929
Rv0120cfusA20.929
Rv0620galK0.926
Rv0620galK0.926
Rv0620galK0.926
Rv2783cgpsI0.921
Rv2783cgpsI0.921
Rv2783cgpsI0.921
Rv2783cgpsI0.921
Rv2783cgpsI0.921
Rv2906ctrmD0.917
Rv2841cnusA0.915
Rv2841cnusA0.915
Rv2445cndkA0.913
Rv0350dnaK0.913
Rv1007cmetS0.908
Rv3461crpmJ0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
spectinomycinPubChem0.936332.35
streptomycinPubChem0.842581.574
magnesiumPubChem0.78624.305
guanosine diphosphatePubChem0.786443.201
zincPubChem0.71265.409