Rv0620

Tuberculist information
Gene namegalK
Protein functionProbable galactokinase GalK (galactose kinase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)712.716
Molecular mass(da)37572.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 363
	  		  	1    MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIP   60
			  	61   LDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAV  120
			  	121  GAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDITVRPVAF  180
			  	181  DPDACDVVLLLMDSRARHCHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIAD  240
			  	241  PIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAES  300
			  	301  AVRAGALGARMTGGGFGGAVIALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAA  360
			  	361  ECR

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 2 to 41  |  Coverage: 10% GalKase_gal_bdg Range: 93 to 161  |  Coverage: 18% GHMP_kinases_N Range: 260 to 342  |  Coverage: 22% GHMP_kinases_C Range: 2 to 363  |  Coverage: 99% 1 Range: 1 to 363  |  Coverage: 99% 1 Range: 186 to 363  |  Coverage: 48% 2 Range: 260 to 342  |  Coverage: 22% 3 Range: 93 to 161  |  Coverage: 18% 4
Number of amino acids : 363
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GalKase_gal_bdgPF105092-41
GHMP_kinases_NPF0028893-161
GHMP_kinases_CPF08544260-342
Mtb Structural Proteome models
Model Number1
Model nameRv0620
Template1WUU    APDBCREDO
Template coverage29_391
Template Identity(%)35.5
Model coverage(%)99.4
Normalized DOPE score-0.371

Structure Models from Chopin
Model Number1
Profiled.14.1.5, d.58.26.7 - 3.30.230.10, 3.30.70.890
Click for model details
zscore61.8
Residue begin1
Residue end363
Model Number2
Profiled.58.26.7
Click for model details
zscore38.27
Residue begin186
Residue end363
Model Number3
Profile3.30.70.890
Click for model details
zscore15.12
Residue begin260
Residue end342
Model Number4
Profiled.14.1.5
Click for model details
zscore12.15
Residue begin93
Residue end161
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0620Gene nameConfidence Score
Rv0618galTa0.999
Rv0619galTb0.999
Rv0993galU0.977
Rv0682rpsL0.976
Rv2528cmrr0.974
Rv2528cmrr0.974
Rv1656argF0.965
Rv1656argF0.965
Rv2427cproA0.965
Rv0667rpoB0.935
Rv0667rpoB0.935
Rv0667rpoB0.935
Rv0667rpoB0.935
Rv0667rpoB0.935
Rv0667rpoB0.935
Rv0721rpsE0.926
Rv0721rpsE0.926
Rv1617pykA0.905
Rv1617pykA0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
galactosePubChem0.994180.156
alpha-galactosePubChem0.992180.156
galactose-1-phosphatePubChem0.978336.316
glucose-1-phosphatePubChem0.976260.136
adenosine diphosphatePubChem0.969427.201
UDP-glucosePubChem0.954566.302
UDP-galactosePubChem0.953566.302
uridine diphosphate galactosePubChem0.95566.302
carboxymethylcellulosePubChem0.915240.208
adenosine triphosphatePubChem0.91507.181
UDP-GlcPubChem0.908566.302
uridine triphosphatePubChem0.906484.141
pyrophosphatePubChem0.905177.975
beta-D-galactosePubChem0.9180.156
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
Aldehydo-D-galactosePubChem0.9180.156
H(+)PubChem0.92.01588
magnesiumPubChem0.7924.305
SeMetPubChem0.78196.106
2-deoxy-D-galactosePubChem0.78164.156
selenomethioninePubChem0.78196.106
glycerolPubChem0.76392.0938
2-deoxy-D-glucosePubChem0.761164.156
phosphatePubChem0.72696.9872