Rv2427c

Tuberculist information
Gene nameproA
Protein functionProbable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialdehyde dehydrogenase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2724.23
Molecular mass(da)43744.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 415
	  		  	1    MTVPAPSQLDLRQEVHDAARRARVAARRLASLPTTVKDRALHAAADELLAHRDQILAANA   60
			  	61   EDLNAAREADTPAAMLDRLSLNPQRVDGIAAGLRQVAGLRDPVGEVLRGYTLPNGLQLRQ  120
			  	121  QRVPLGVVGMIYEGRPNVTVDAFGLTLKSGNAALLRGSSSAAKSNEALVAVLRTALVGLE  180
			  	181  LPADAVQLLSAADRATVTHLIQARGLVDVVIPRGGAGLIEAVVRDAQVPTIETGVGNCHV  240
			  	241  YVHQAADLDVAERILLNSKTRRPSVCNAAETLLVDAAIAETALPRLLAALQHAGVTVHLD  300
			  	301  PDEADLRREYLSLDIAVAVVDGVDAAIAHINEYGTGHTEAIVTTNLDAAQRFTEQIDAAA  360
			  	361  VMVNASTAFTDGEQFGFGAEIGISTQKLHARGPMGLPELTSTKWIAWGAGHTRPA

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 5 to 306  |  Coverage: 72% Aldedh Range: 315 to 405  |  Coverage: 21% Aldedh Range: 13 to 414  |  Coverage: 96% 1 Range: 1 to 302  |  Coverage: 72% 1 Range: 315 to 616  |  Coverage: 72% 2
Number of amino acids : 415
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AldedhPF001715-306
AldedhPF00171315-405
Mtb Structural Proteome models
Model Number1
Model nameRv2427c
Template1O20    APDBCREDO
Template coverage2_415
Template Identity(%)47.5
Model coverage(%)96.6
Normalized DOPE score-0.409

Structure Models from Chopin
Model Number1
Profilec.82.1.1
Click for model details
zscore13.84
Residue begin1
Residue end302
Model Number2
Profilec.82.1.1
Click for model details
zscore13.84
Residue begin315
Residue end616
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2427cGene nameConfidence Score
Rv2439cproB0.999
Rv2439cproB0.999
Rv0500proC0.998
Rv0500proC0.998
Rv1656argF0.98
Rv1656argF0.98
Rv2528cmrr0.973
Rv2528cmrr0.973
Rv0993galU0.969
Rv0620galK0.965
Rv0620galK0.965
Rv0620galK0.965
Rv2756chsdM0.962
Rv2756chsdM0.962
Rv0682rpsL0.957
Rv2442crplU0.938
Rv1652argC0.928
Rv1652argC0.928
Rv3356cfolD0.924
Rv3356cfolD0.924
Rv1187rocA0.92
Rv1659argH0.918
Rv1659argH0.918
Rv1689tyrS0.903
Rv1689tyrS0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glutamate semialdehydePubChem0.983131.13
pyrroline-5-carboxylatePubChem0.982113.115
1-pyrroline-5-carboxylatePubChem0.978113.115
gamma-glutamyl phosphatePubChem0.971227.109
glutamatePubChem0.968147.129
glutamate gamma-semialdehydePubChem0.956131.13
ornithinePubChem0.954132.161
phosphatePubChem0.93996.9872
NADPPubChem0.923744.413
alpha-ketoglutaratePubChem0.921146.098
H(+)PubChem0.9032.01588
deuteriumPubChem0.9032.01588
C03287PubChem0.9227.109
protiumPubChem0.92.01576
adenosine diphosphatePubChem0.9427.201
hydroxyl radicalsPubChem0.917.0073
NADP(H)PubChem0.9745.421
adenosine triphosphatePubChem0.9507.181
selenomethioninePubChem0.795196.106
SeMetPubChem0.795196.106