Rv2439c

Tuberculist information
Gene nameproB
Protein functionProbable glutamate 5-kinase protein ProB (gamma-glutamyl kinase) (GK)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2737.12
Molecular mass(da)38788.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 376
	  		  	1    MRSPHRDAIRTARGLVVKVGTTALTTPSGMFDAGRLAGLAEAVERRMKAGSDVVIVSSGA   60
			  	61   IAAGIEPLGLSRRPKDLATKQAAASVGQVALVNSWSAAFARYGRTVGQVLLTAHDISMRV  120
			  	121  QHTNAQRTLDRLRALHAVAIVNENDTVATNEIRFGDNDRLSALVAHLVGADALVLLSDID  180
			  	181  GLYDCDPRKTADATFIPEVSGPADLDGVVAGRSSHLGTGGMASKVAAALLAADAGVPVLL  240
			  	241  APAADAATALADASVGTVFAARPARLSARRFWVRYAAEATGALTLDAGAVRAVVRQRRSL  300
			  	301  LAAGITAVSGRFCGGDVVELRAPDAAMVARGVVAYDASELATMVGRSTSELPGELRRPVV  360
			  	361  HADDLVAVSAKQAKQV

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 13 to 241  |  Coverage: 60% AA_kinase Range: 281 to 355  |  Coverage: 19% PUA Range: 13 to 251  |  Coverage: 63% 1 Range: 13 to 241  |  Coverage: 60% 1 Range: 281 to 355  |  Coverage: 19% 2 Range: 6 to 375  |  Coverage: 98% 3
Number of amino acids : 376
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AA_kinasePF0069613-241
PUAPF01472281-355
Mtb Structural Proteome models
Model Number1
Model nameRv2439c
Template2AKO    APDBCREDO
Template coverage2_237
Template Identity(%)35.2
Model coverage(%)63.3
Normalized DOPE score-0.385

Structure Models from Chopin
Model Number1
Profilec.73.1.3 - 3.40.1160.10
Click for model details
zscore18.86
Residue begin13
Residue end241
Model Number2
Profile2.30.130.10
Click for model details
zscore11.68
Residue begin281
Residue end355
Model Number3
Profilec.73.1.3 - 3.40.1160.10
Click for model details
zscore9.47
Residue begin6
Residue end375
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2439cGene nameConfidence Score
Rv2427cproA0.999
Rv2440cobg0.987
Rv2440cobg0.987
Rv2440cobg0.987
Rv2442crplU0.978
Rv1658argG0.976
Rv0500proC0.966
Rv0500proC0.966
Rv1653argJ0.951
Rv2476cgdh0.939
Rv2441crpmA0.932
Rv1380pyrB0.926
Rv1380pyrB0.926
Rv2995cleuB0.925
Rv1654argB0.922
Rv1187rocA0.919
Rv3275cpurE0.913
Rv3674cnth0.913
Rv3674cnth0.913
Rv3674cnth0.913
Rv2225panB0.911
Rv1652argC0.908
Rv1652argC0.908
Rv1656argF0.902
Rv1656argF0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glutamatePubChem0.99147.129
gamma-glutamyl phosphatePubChem0.987227.109
glutamate semialdehydePubChem0.966131.13
adenosine diphosphatePubChem0.963427.201
glutamate gamma-semialdehydePubChem0.95131.13
NADPPubChem0.914744.413
phosphatePubChem0.90796.9872
hydroxyl radicalsPubChem0.917.0073
polyglutaminePubChem0.9146.145
protiumPubChem0.92.01576
ammoniaPubChem0.917.0305
NADP(H)PubChem0.9745.421
H(+)PubChem0.92.01588
C03287PubChem0.9227.109
deuteriumPubChem0.92.01588
adenosine triphosphatePubChem0.9507.181
glutaminPubChem0.9146.145
L-prolinePubChem0.875115.13
pyroglutamic acidPubChem0.778129.114
L-azetidine-2-carboxylic acidPubChem0.756101.104
magnesiumPubChem0.70324.305