SInCRe - Rv1653

Tuberculist information

Gene name	argJ
Protein function	Probable glutamate N-acetyltransferase ArgJ
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1866.63
Molecular mass(da)	41115.3
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 404

	  		  	1    VTDLAGTTRLLRAQGVTAPAGFRAAGVAAGIKASGALDLALVFNEGPDYAAAGVFTRNQV   60
			  	61   KAAPVLWTQQVLTTGRLRAVILNSGGANACTGPAGFADTHATAEAVAAALSDWGTETGAI  120
			  	121  EVAVCSTGLIGDRLPMDKLLAGVAHVVHEMHGGLVGGDEAAHAIMTTDNVPKQVALHHHD  180
			  	181  NWTVGGMAKGAGMLAPSLATMLCVLTTDAAAEPAALERALRRAAAATFDRLDIDGSCSTN  240
			  	241  DTVLLLSSGASEIPPAQADLDEAVLRVCDDLCAQLQADAEGVTKRVTVTVTGAATEDDAL  300
			  	301  VAARQIARDSLVKTALFGSDPNWGRVLAAVGMAPITLDPDRISVSFNGAAVCVHGVGAPG  360
			  	361  AREVDLSDADIDITVDLGVGDGQARIRTTDLSHAYVEENSAYSS

Known structures in the PDB

	PDB ID	3IT4
	Total residue count	808
	Number of chains	4
	Method	X-RAY
	Resolution	1.7

	PDB ID	3IT6
	Total residue count	808
	Number of chains	4
	Method	X-RAY
	Resolution	2.4

Number of amino acids : 404

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
ArgJ	PF01960	22-404

Mtb Structural Proteome models

Model Number	1
Model name	Rv1653_3it4_A
Template	3IT4 APDB CREDO
Template coverage	7_199
Template Identity(%)	100.0
Model coverage(%)	47.5
Normalized DOPE score	-0.429

Model Number	2
Model name	Rv1653_3it4_C
Template	3IT4 CPDB CREDO
Template coverage	7_199
Template Identity(%)	100.0
Model coverage(%)	47.5
Normalized DOPE score	-0.406

Model Number	3
Model name	Rv1653
Template	1VZ6 APDB CREDO
Template coverage	9_389
Template Identity(%)	34.5
Model coverage(%)	94.3
Normalized DOPE score	-0.023

Structure Models from Chopin

Model Number	1
Profile	d.154.1.2 Click for model details
zscore	61.98
Residue begin	18
Residue end	401

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1653	Gene name	Confidence Score
Rv1658	argG	0.999
Rv1654	argB	0.999
Rv1655	argD	0.999
Rv1656	argF	0.999
Rv1656	argF	0.999
Rv1652	argC	0.999
Rv1652	argC	0.999
Rv1659	argH	0.996
Rv1659	argH	0.996
Rv1657	argR	0.992
Rv1657	argR	0.992
Rv2747	argA	0.991
Rv1383	carA	0.97
Rv1383	carA	0.97
Rv1380	pyrB	0.962
Rv1380	pyrB	0.962
Rv2439c	proB	0.951
Rv2439c	proB	0.951
Rv1187	rocA	0.949
Rv1384	carB	0.942
Rv1384	carB	0.942
Rv1384	carB	0.942
Rv1384	carB	0.942
Rv2321c	rocD2	0.929
Rv0357c	purA	0.926
Rv2322c	rocD1	0.922
Rv3240c	secA1	0.92
Rv3240c	secA1	0.92
Rv3240c	secA1	0.92
Rv2476c	gdh	0.91
Rv2988c	leuC	0.91

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
ornithinePubChem	0.999	132.161
acetylornithinePubChem	0.995	174.198
N-acetylglutamatePubChem	0.988	189.166
glutamatePubChem	0.98	147.129
acetyl-CoAPubChem	0.973	809.571
citrullinePubChem	0.96	175.186
phosphatePubChem	0.92	96.9872
Co-APubChem	0.9	767.534
benzoic acidPubChem	0.9	121.113
N-acetyl-L-glutamic acid gamma-semialdehydePubChem	0.9	173.167
hydride acetatePubChem	0.9	61.0599
coenzyme APubChem	0.9	767.534
acetatePubChem	0.9	59.044
H(+)PubChem	0.9	2.01588
deuteriumPubChem	0.9	2.01588
N-acetylglutamyl-phosphatePubChem	0.9	269.146
adenosine triphosphatePubChem	0.9	507.181
N-acetyl-L-glutamyl-5-phosphatePubChem	0.9	269.146
protiumPubChem	0.9	2.01576
carbamoyl phosphatePubChem	0.9	141.02
alpha-ketoglutaratePubChem	0.9	146.098
acetyl coenzyme-APubChem	0.9	809.571
glycerolPubChem	0.9	92.0938
citrullinPubChem	0.9	175.186
adenosine diphosphatePubChem	0.9	427.201