Rv2321c

Tuberculist information
Gene namerocD2
Protein functionProbable ornithine aminotransferase (C-terminus part) RocD2 (ornithine--oxo-acid aminotransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2594.15
Molecular mass(da)18880.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 181
	  		  	1    MIADEIQSGLACTGYPFACDHGGVLPDIYLLGKTLGGGAVPLSAMVADREIFGVVHPGEH   60
			  	61   GSTFGGNPLAAAIGTPVVSMVVWGECQARSAKLGAHLHQRLADLIGDGAVALRGLGWWAD  120
			  	121  VDIERALAIGTDMSMRLADRGVLLKDTYGAALRFAPPLVITAQEIDCAVRRFADALWEAG  180
			  	181  S

Known structures in the PDB
No Known structures
1 19 37 55 73 91 109 127 145 163 181 Range: 1 to 125  |  Coverage: 68% Aminotran_3 Range: 1 to 178  |  Coverage: 97% 1 Range: 1 to 181  |  Coverage: 99% 1
Number of amino acids : 181
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Aminotran_3PF002021-125
Mtb Structural Proteome models
Model Number1
Model nameRv2321c
Template2OAT    APDBCREDO
Template coverage260_438
Template Identity(%)39.3
Model coverage(%)97.3
Normalized DOPE score0.415

Structure Models from Chopin
Model Number1
Profilec.67.1.4
Click for model details
zscore15.26
Residue begin1
Residue end181
Binding pockets
STRING
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Protein interacting with Rv2321cGene nameConfidence Score
Rv2322crocD10.999
Rv2323cRv2323c0.966
Rv1187rocA0.949
Rv1653argJ0.929
Rv1656argF0.927
Rv1656argF0.927
Rv2320crocE0.922
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ornithinePubChem0.903132.161
SUOPubChem0.9232.234
alpha-ketoglutaratePubChem0.9146.098
C05932PubChem0.9231.203
glutamate semialdehydePubChem0.9131.13
glutamate gamma-semialdehydePubChem0.9131.13
glutamatePubChem0.9147.129