Rv2322c

Tuberculist information
Gene namerocD1
Protein functionProbable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2594.7
Molecular mass(da)22714.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 221
	  		  	1    MTNLADATQATMALVERHAAHNYSPLPVVAASAEGAWIADIDGLRYLDWLAAYSAVNLGH   60
			  	61   RNPASTATAHAQVDTVTLLNRALHADRLGPLGAALAQLCGKDVVLPMNSDAEAVESGLRV  120
			  	121  ARKWGADVNGLPAGRHDIILANNNFHGHTSSVVSFSSDPAAGSGVEPSTPGLRSVPFGDA  180
			  	181  AAPAQTIDDNTVADLLEPIPGQAGIIVPADDYLPAASSTTC

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 29 to 221  |  Coverage: 86% Aminotran_3 Range: 5 to 220  |  Coverage: 97% 1 Range: 1 to 221  |  Coverage: 99% 1
Number of amino acids : 221
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Aminotran_3PF0020229-221
Mtb Structural Proteome models
Model Number1
Model nameRv2322c
Template2OAT    APDBCREDO
Template coverage37_253
Template Identity(%)36.1
Model coverage(%)97.3
Normalized DOPE score1.394

Structure Models from Chopin
Model Number1
Profilec.67.1.4
Click for model details
zscore22.83
Residue begin1
Residue end221
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2322cGene nameConfidence Score
Rv2321crocD20.999
Rv2320crocE0.976
Rv1187rocA0.962
Rv1656argF0.94
Rv1656argF0.94
Rv2323cRv2323c0.926
Rv1653argJ0.922
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ornithinePubChem0.913132.161
glutamate semialdehydePubChem0.908131.13
glutamate gamma-semialdehydePubChem0.906131.13
alpha-ketoglutaratePubChem0.904146.098
glutamatePubChem0.904147.129
SUOPubChem0.9232.234
C05932PubChem0.9231.203