Rv2756c

Tuberculist information
Gene namehsdM
Protein functionPossible type I restriction/modification system DNA methylase HsdM (M protein) (DNA methyltransferase)
Functional category(tuberculist)information pathways
Gene location(kb)3068.46
Molecular mass(da)60084.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 540
	  		  	1    MPPRKKQAPQAPSTMKELKDTLWKAADKLRGSLSASQYKDVILGLVFLKYVSDAYDERRE   60
			  	61   AIRAELAAEGMEESQIEDLIDDPEQYQGYGVFVVPVSARWKFLAENTKGKPAVGGEPAKN  120
			  	121  IGQLIDEAMDAVMKANPTLGGTLPRLYNKDNIDQRRLGELIDLFNSARFSRQGEHRARDL  180
			  	181  MGEVYEYFLGNFARAEGKRGGEFFTPPSVVKVIVEVLEPSSGRVYDPCCGSGGMFVQTEK  240
			  	241  FIYEHDGDPKDVSIYGQESIEETWRMAKMNLAIHGIDNKGLGARWSDTFARDQHPDVQMD  300
			  	301  YVMANLPFNIKDWARNEEDPRWRFGVPPANNANYAWIQHILYKLAPGGRAGVVMANGSMS  360
			  	361  SNSNGEGDIRAQIVEADLVSCMVALPTQLFRSTGIPVCLWFFAKDKAAGKQGSIDRCGQV  420
			  	421  LFIDARELGDLVDRAERALTNEEIVRIGDTFHAWRGSKSAAVKGIMYEDVPGFCKSATLA  480
			  	481  EIKATDYALTPGRYVGTPAVEDDGEPIDEKMARLSKALLEAFDESARLERVVREQLGRLR  540

Known structures in the PDB
No Known structures
1 55 109 163 217 271 325 379 433 487 541 Range: 18 to 164  |  Coverage: 27% HsdM_N Range: 176 to 503  |  Coverage: 60% N6_Mtase Range: 16 to 532  |  Coverage: 95% 1 Range: 10 to 540  |  Coverage: 98% 1
Number of amino acids : 540
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HsdM_NPF1216118-164
N6_MtasePF02384176-503
Mtb Structural Proteome models
Model Number1
Model nameRv2756c
Template2AR0    APDBCREDO
Template coverage6_509
Template Identity(%)23.0
Model coverage(%)95.6
Normalized DOPE score0.693

Structure Models from Chopin
Model Number1
Profilec.66.1.45
Click for model details
zscore43.49
Residue begin10
Residue end540
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2756cGene nameConfidence Score
Rv2761chsdS0.988
Rv0682rpsL0.967
Rv2427cproA0.962
Rv1656argF0.96
Rv1656argF0.96
Rv2755chsdS.10.948
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions