Rv2761c

Tuberculist information
Gene namehsdS
Protein functionPossible type I restriction/modification system specificity determinant HsdS (S protein)
Functional category(tuberculist)information pathways
Gene location(kb)3071.55
Molecular mass(da)39211.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 364
	  		  	1    MSRVEKVEKVRLGDHLDFSNGHTSGHTSPASEPGGRYPVYGANGVIGYSAQHNARGPLIV   60
			  	61   VGRVGSYCGSLRYCDSDVWVTDNALACRAKKPEETRYWYYALLGFGLNRYRAGSGQPLLS  120
			  	121  QGVLRNVSVSAVAAPDRPRIGEILGAFDDKIAANDRVIEAAEALMLAIVGRLSAYVPLSS  180
			  	181  LASRSTACLDAQHFDSTVAHYSFAAFDGGAQPSRVGGRTIRSAKLVVSQPCVLFPKLNPR  240
			  	241  IPRIWNITSLPSEMALASTEFVVLRPVGVDTSALWAALRQPDVLAELRQLVGGMTGSRQR  300
			  	301  IQPTQLLRVWVRDVRRLTPGHAAAIANLGALCNERRIESARLASCRDALLPLLMSGIDGL  360
			  	361  PAGR

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 4 to 163  |  Coverage: 43% Methylase_S Range: 6 to 354  |  Coverage: 95% 1 Range: 1 to 188  |  Coverage: 51% 1
Number of amino acids : 364
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Methylase_SPF014204-163
Mtb Structural Proteome models
Model Number1
Model nameRv2761c
Template1YDX    APDBCREDO
Template coverage12_370
Template Identity(%)15.5
Model coverage(%)95.6
Normalized DOPE score0.305

Structure Models from Chopin
Model Number1
Profiled.287.1.2
Click for model details
zscore12.63
Residue begin1
Residue end188
Binding pockets
STRING
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Protein interacting with Rv2761cGene nameConfidence Score
Rv2756chsdM0.988
Rv2756chsdM0.988
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions