SInCRe - Rv0641

Tuberculist information

Gene name	rplA
Protein function	50S ribosomal protein L1 RplA
Functional category(tuberculist)	information pathways
Gene location(kb)	735.517
Molecular mass(da)	24756.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 235

	  		  	1    MSKTSKAYRAAAAKVDRTNLYTPLQAAKLAKETSSTKQDATVEVAIRLGVDPRKADQMVR   60
			  	61   GTVNLPHGTGKTARVAVFAVGEKADAAVAAGADVVGSDDLIERIQGGWLEFDAAIATPDQ  120
			  	121  MAKVGRIARVLGPRGLMPNPKTGTVTADVAKAVADIKGGKINFRVDKQANLHFVIGKASF  180
			  	181  DEKLLAENYGAAIDEVLRLKPSSSKGRYLKKITVSTTTGPGIPVDPSITRNFAGE

Known structures in the PDB

No Known structures

Number of amino acids : 235

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Ribosomal_L1	PF00687	5-221

Mtb Structural Proteome models

Model Number	1
Model name	Rv0641
Template	1AD2 APDB CREDO
Template coverage	5_226
Template Identity(%)	48.9
Model coverage(%)	93.6
Normalized DOPE score	-0.696

Structure Models from Chopin

Model Number	1
Profile	e.24.1.1 Click for model details
zscore	37.17
Residue begin	6
Residue end	229

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0641	Gene name	Confidence Score
Rv0719	rplF	0.999
Rv0640	rplK	0.999
Rv0701	rplC	0.999
Rv0640	rplK	0.999
Rv0702	rplD	0.999
Rv0716	rplE	0.999
Rv0056	rplI	0.999
Rv0716	rplE	0.999
Rv0056	rplI	0.999
Rv0652	rplL	0.999
Rv0714	rplN	0.998
Rv0720	rplR	0.998
Rv0721	rpsE	0.998
Rv0651	rplJ	0.998
Rv3443c	rplM	0.998
Rv0721	rpsE	0.998
Rv0703	rplW	0.998
Rv0708	rplP	0.998
Rv3456c	rplQ	0.998
Rv0704	rplB	0.998
Rv0723	rplO	0.998
Rv0704	rplB	0.998
Rv0684	fusA1	0.997
Rv0684	fusA1	0.997
Rv0706	rplV	0.997
Rv0715	rplX	0.997
Rv3458c	rpsD	0.997
Rv0684	fusA1	0.997
Rv3458c	rpsD	0.997
Rv0684	fusA1	0.997
Rv0682	rpsL	0.997
Rv2890c	rpsB	0.997
Rv2904c	rplS	0.997
Rv0684	fusA1	0.997
Rv0639	nusG	0.996
Rv2889c	tsf	0.996
Rv2889c	tsf	0.996
Rv2441c	rpmA	0.996
Rv0639	nusG	0.996
Rv0718	rpsH	0.995
Rv0710	rpsQ	0.995
Rv0705	rpsS	0.995
Rv0700	rpsJ	0.995
Rv0707	rpsC	0.995
Rv0707	rpsC	0.995
Rv0683	rpsG	0.995
Rv3460c	rpsM	0.995
Rv3459c	rpsK	0.994
Rv1643	rplT	0.994
Rv0667	rpoB	0.993
Rv3457c	rpoA	0.993
Rv0667	rpoB	0.993
Rv3457c	rpoA	0.993
Rv0667	rpoB	0.993
Rv0667	rpoB	0.993
Rv0667	rpoB	0.993
Rv0667	rpoB	0.993
Rv3457c	rpoA	0.993
Rv2442c	rplU	0.992
Rv0668	rpoC	0.991
Rv0668	rpoC	0.991
Rv0668	rpoC	0.991
Rv0668	rpoC	0.991
Rv0668	rpoC	0.991
Rv0634B	rpmG2	0.99
Rv0685	tuf	0.989
Rv2057c	rpmG1	0.989
Rv3442c	rpsI	0.989
Rv0685	tuf	0.989
Rv0685	tuf	0.989
Rv2882c	frr	0.983
Rv0709	rpmC	0.977
Rv0722	rpmD	0.976
Rv0717	rpsN1	0.976
Rv0053	rpsF	0.974
Rv1630	rpsA	0.972
Rv1015c	rplY	0.97
Rv1015c	rplY	0.97
Rv2839c	infB	0.969
Rv2839c	infB	0.969
Rv2839c	infB	0.969
Rv2839c	infB	0.969
Rv3462c	infA	0.968
Rv1298	rpmE	0.965
Rv2056c	rpsN2	0.961
Rv0732	secY	0.958
Rv2906c	trmD	0.948
Rv0120c	fusA2	0.942
Rv0120c	fusA2	0.942
Rv0120c	fusA2	0.942
Rv0120c	fusA2	0.942
Rv0120c	fusA2	0.942
Rv0055	rpsR1	0.941
Rv2909c	rpsP	0.939
Rv2462c	tig	0.937
Rv2462c	tig	0.937
Rv2462c	tig	0.937
Rv1308	atpA	0.935
Rv1308	atpA	0.935
Rv1641	infC	0.935
Rv1641	infC	0.935
Rv1308	atpA	0.935
Rv2841c	nusA	0.931
Rv2841c	nusA	0.931
Rv2785c	rpsO	0.928
Rv1023	eno	0.924
Rv1023	eno	0.924
Rv0733	adk	0.921
Rv2992c	gltS	0.92
Rv1112	Rv1112	0.913
Rv1112	Rv1112	0.913
Rv3924c	rpmH	0.91
Rv0350	dnaK	0.91
Rv1297	rho	0.908
Rv1297	rho	0.908
Rv1297	rho	0.908
Rv2783c	gpsI	0.904
Rv2058c	rpmB2	0.904
Rv2783c	gpsI	0.904
Rv2783c	gpsI	0.904
Rv2783c	gpsI	0.904
Rv2783c	gpsI	0.904
Rv3461c	rpmJ	0.902

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
SeMetPubChem	0.792	196.106
selenomethioninePubChem	0.792	196.106
magnesiumPubChem	0.747	24.305
ara-TMPPubChem	0.705	338.208
2-methyl-2,4-pentanediolPubChem	0.705	118.174
[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl phosphatePubChem	0.705	338.208
ammoniaPubChem	0.705	17.0305
zincPubChem	0.705	65.409
potassiumPubChem	0.705	39.0983
potassium hydridePubChem	0.705	40.1062
sulfatePubChem	0.705	96.0626
MRDPubChem	0.705	118.174
1,4-butanediolPubChem	0.705	90.121
hydron sulfatePubChem	0.705	196.157
mercuryPubChem	0.705	200.59
formatePubChem	0.705	45.0174