SInCRe - Rv1630

Tuberculist information

Gene name	rpsA
Protein function	30S ribosomal protein S1 RpsA
Functional category(tuberculist)	information pathways
Gene location(kb)	1833.54
Molecular mass(da)	53201.8
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 481

	  		  	1    MPSPTVTSPQVAVNDIGSSEDFLAAIDKTIKYFNDGDIVEGTIVKVDRDEVLLDIGYKTE   60
			  	61   GVIPARELSIKHDVDPNEVVSVGDEVEALVLTKEDKEGRLILSKKRAQYERAWGTIEALK  120
			  	121  EKDEAVKGTVIEVVKGGLILDIGLRGFLPASLVEMRRVRDLQPYIGKEIEAKIIELDKNR  180
			  	181  NNVVLSRRAWLEQTQSEVRSEFLNNLQKGTIRKGVVSSIVNFGAFVDLGGVDGLVHVSEL  240
			  	241  SWKHIDHPSEVVQVGDEVTVEVLDVDMDRERVSLSLKATQEDPWRHFARTHAIGQIVPGK  300
			  	301  VTKLVPFGAFVRVEEGIEGLVHISELAERHVEVPDQVVAVGDDAMVKVIDIDLERRRISL  360
			  	361  SLKQANEDYTEEFDPAKYGMADSYDEQGNYIFPEGFDAETNEWLEGFEKQRAEWEARYAE  420
			  	421  AERRHKMHTAQMEKFAAAEAAGRGADDQSSASSAPSEKTAGGSLASDAQLAALREKLAGS  480
			  	481  A

Known structures in the PDB

No Known structures

Number of amino acids : 481

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
S1	PF00575	32-105
S1	PF00575	119-188
S1	PF00575	205-277
S1	PF00575	290-363

Mtb Structural Proteome models

Model Number	1
Model name	Rv1630
Template	2CQO APDB CREDO
Template coverage	5_92
Template Identity(%)	42.2
Model coverage(%)	17.0
Normalized DOPE score	-0.186

Model Number	2
Model name	Rv1630.3
Template	2A19 APDB CREDO
Template coverage	13_150
Template Identity(%)	21.5
Model coverage(%)	29.1
Normalized DOPE score	0.261

Model Number	3
Model name	Rv1630.2
Template	1SRO APDB CREDO
Template coverage	2_76
Template Identity(%)	44.0
Model coverage(%)	15.6
Normalized DOPE score	0.296

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1630	Gene name	Confidence Score
Rv1712	cmk	0.989
Rv2890c	rpsB	0.988
Rv0721	rpsE	0.98
Rv0721	rpsE	0.98
Rv0651	rplJ	0.972
Rv0641	rplA	0.972
Rv0683	rpsG	0.97
Rv3458c	rpsD	0.969
Rv3458c	rpsD	0.969
Rv0006	gyrA	0.967
Rv0006	gyrA	0.967
Rv0682	rpsL	0.964
Rv0700	rpsJ	0.964
Rv2889c	tsf	0.962
Rv2889c	tsf	0.962
Rv2462c	tig	0.96
Rv2462c	tig	0.96
Rv2462c	tig	0.96
Rv3459c	rpsK	0.959
Rv2534c	efp	0.957
Rv2534c	efp	0.957
Rv2534c	efp	0.957
Rv2441c	rpmA	0.954
Rv0053	rpsF	0.952
Rv0701	rplC	0.952
Rv0704	rplB	0.949
Rv0704	rplB	0.949
Rv0707	rpsC	0.948
Rv0707	rpsC	0.948
Rv1297	rho	0.947
Rv1297	rho	0.947
Rv1297	rho	0.947
Rv1110	lytB2	0.946
Rv2783c	gpsI	0.945
Rv2783c	gpsI	0.945
Rv0706	rplV	0.945
Rv2783c	gpsI	0.945
Rv2783c	gpsI	0.945
Rv2783c	gpsI	0.945
Rv3457c	rpoA	0.943
Rv3457c	rpoA	0.943
Rv3457c	rpoA	0.943
Rv2839c	infB	0.941
Rv2839c	infB	0.941
Rv2839c	infB	0.941
Rv2839c	infB	0.941
Rv1650	pheT	0.94
Rv1650	pheT	0.94
Rv1650	pheT	0.94
Rv1650	pheT	0.94
Rv3443c	rplM	0.938
Rv2904c	rplS	0.936
Rv3456c	rplQ	0.935
Rv0703	rplW	0.934
Rv2555c	alaS	0.933
Rv2555c	alaS	0.933
Rv2555c	alaS	0.933
Rv0684	fusA1	0.932
Rv0684	fusA1	0.932
Rv0684	fusA1	0.932
Rv0684	fusA1	0.932
Rv0684	fusA1	0.932
Rv1631	coaE	0.93
Rv1631	coaE	0.93
Rv2364c	era	0.924
Rv2364c	era	0.924
Rv2992c	gltS	0.922
Rv3382c	lytB1	0.919
Rv0640	rplK	0.917
Rv0640	rplK	0.917
Rv0652	rplL	0.916
Rv1641	infC	0.915
Rv1641	infC	0.915
Rv2841c	nusA	0.912
Rv2841c	nusA	0.912
Rv0350	dnaK	0.911
Rv2737c	recA	0.91
Rv2737c	recA	0.91
Rv1007c	metS	0.902
Rv0732	secY	0.901

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv1630.2	2	4dta_ADN_A_401 PDB CREDO	0.635	0.139	0.607	0.002
Rv1630.2	2	2y7j_B49_D_1294 PDB CREDO	0.578	0.206	0.553	0.005
Rv1630.2	2	4dt8_ADN_A_401 PDB CREDO	0.573	0.213	0.547	0.005
Rv1630.2	2	1uay_ADN_A_1001 PDB CREDO	0.534	0.267	0.534	0.006
Rv1630.3	7	1uay_ADN_A_1001 PDB CREDO	0.568	0.220	0.519	0.008
Rv1630.2	2	1xwf_ADN_B_433 PDB CREDO	0.539	0.259	0.515	0.009
Rv1630.2	2	1xwf_ADN_D_433 PDB CREDO	0.539	0.259	0.515	0.009
Rv1630.2	2	2y7j_B49_C_1294 PDB CREDO	0.594	0.186	0.515	0.009
Rv1630.2	2	1xwf_ADN_A_433 PDB CREDO	0.538	0.261	0.514	0.009
Rv1630.2	2	1xwf_ADN_C_433 PDB CREDO	0.535	0.266	0.511	0.009
Rv1630.2	2	1pg2_ADN_A_552 PDB CREDO	0.532	0.270	0.507	0.010
Rv1630.3	7	3lfa_1N1_A_361 PDB CREDO	0.551	0.243	0.505	0.010
Rv1630.2	2	2y7j_B49_A_1294 PDB CREDO	0.505	0.310	0.505	0.010
Rv1630.3	7	2y7j_B49_D_1294 PDB CREDO	0.524	0.281	0.501	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions