Rv0640

Tuberculist information
Gene namerplK
Protein function50S ribosomal protein L11 RplK
Functional category(tuberculist)information pathways
Gene location(kb)735.022
Molecular mass(da)15003.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 142
	  		  	1    MAPKKKVAGLIKLQIVAGQANPAPPVGPALGQHGVNIMEFCKAYNAATENQRGNVIPVEI   60
			  	61   TVYEDRSFTFTLKTPPAAKLLLKAAGVAKGSAEPHKTKVAKVTWDQVREIAETKKTDLNA  120
			  	121  NDVDAAAKIIAGTARSMGITVE

Known structures in the PDB
No Known structures
1 15 29 43 57 71 85 99 113 127 141 Range: 10 to 68  |  Coverage: 40% Ribosomal_L11_N Range: 73 to 141  |  Coverage: 47% Ribosomal_L11 Range: 5 to 142  |  Coverage: 96% 1 Range: 4 to 142  |  Coverage: 97% 1 Range: 3 to 73  |  Coverage: 49% 2 Range: 69 to 142  |  Coverage: 51% 3
Number of amino acids : 142
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ribosomal_L11_NPF0394610-68
Ribosomal_L11PF0029873-141
Mtb Structural Proteome models
Model Number1
Model nameRv0640
Template1NKW    GPDBCREDO
Template coverage2_139
Template Identity(%)65.9
Model coverage(%)96.5
Normalized DOPE score0.954

Structure Models from Chopin
Model Number1
Profilea.4.7.1, d.47.1.1
Click for model details
zscore30.51
Residue begin4
Residue end142
Model Number2
Profile3.30.1550.10
Click for model details
zscore22.93
Residue begin3
Residue end73
Model Number3
Profilea.4.7.1 - 1.10.10.250
Click for model details
zscore20.62
Residue begin69
Residue end142
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0640Gene nameConfidence Score
Rv0641rplA0.999
Rv0702rplD0.999
Rv0716rplE0.999
Rv0716rplE0.999
Rv0652rplL0.999
Rv0708rplP0.999
Rv0704rplB0.999
Rv0704rplB0.999
Rv0719rplF0.999
Rv0714rplN0.999
Rv0701rplC0.999
Rv0707rpsC0.998
Rv0651rplJ0.998
Rv0707rpsC0.998
Rv0682rpsL0.998
Rv0703rplW0.998
Rv0706rplV0.998
Rv3456crplQ0.997
Rv0723rplO0.997
Rv0720rplR0.997
Rv0715rplX0.997
Rv3443crplM0.997
Rv3460crpsM0.996
Rv2904crplS0.996
Rv0056rplI0.996
Rv2441crpmA0.996
Rv0056rplI0.996
Rv0639nusG0.996
Rv0700rpsJ0.996
Rv0639nusG0.996
Rv0721rpsE0.995
Rv3459crpsK0.995
Rv0667rpoB0.995
Rv0684fusA10.995
Rv0721rpsE0.995
Rv0667rpoB0.995
Rv0685tuf0.995
Rv0685tuf0.995
Rv0667rpoB0.995
Rv0684fusA10.995
Rv0685tuf0.995
Rv0667rpoB0.995
Rv0684fusA10.995
Rv0667rpoB0.995
Rv0684fusA10.995
Rv0667rpoB0.995
Rv0684fusA10.995
Rv0710rpsQ0.993
Rv0705rpsS0.993
Rv3458crpsD0.993
Rv1643rplT0.993
Rv3458crpsD0.993
Rv0683rpsG0.992
Rv0718rpsH0.992
Rv2442crplU0.991
Rv3457crpoA0.99
Rv3457crpoA0.99
Rv3457crpoA0.99
Rv0634BrpmG20.989
Rv0717rpsN10.988
Rv0709rpmC0.988
Rv2056crpsN20.987
Rv3442crpsI0.986
Rv2889ctsf0.985
Rv2889ctsf0.985
Rv0668rpoC0.983
Rv0668rpoC0.983
Rv0668rpoC0.983
Rv0668rpoC0.983
Rv0668rpoC0.983
Rv0732secY0.982
Rv2057crpmG10.982
Rv2890crpsB0.98
Rv3461crpmJ0.979
Rv0722rpmD0.974
Rv1298rpmE0.972
Rv2882cfrr0.972
Rv0053rpsF0.97
Rv1015crplY0.969
Rv1015crplY0.969
Rv0055rpsR10.961
Rv1641infC0.958
Rv1641infC0.958
Rv2150cftsZ0.957
Rv2150cftsZ0.957
Rv2909crpsP0.954
Rv2906ctrmD0.953
Rv2916cffh0.951
Rv2916cffh0.951
Rv2916cffh0.951
Rv2839cinfB0.948
Rv2839cinfB0.948
Rv2839cinfB0.948
Rv2839cinfB0.948
Rv3462cinfA0.947
Rv1023eno0.946
Rv1023eno0.946
Rv2785crpsO0.944
Rv1112Rv11120.938
Rv1112Rv11120.938
Rv2992cgltS0.937
Rv1699pyrG0.93
Rv2412rpsT0.93
Rv1699pyrG0.93
Rv2462ctig0.924
Rv2462ctig0.924
Rv2462ctig0.924
Rv2058crpmB20.923
Rv1017cprsA0.92
Rv1017cprsA0.92
Rv2448cvalS0.917
Rv0120cfusA20.917
Rv2448cvalS0.917
Rv0120cfusA20.917
Rv0120cfusA20.917
Rv1630rpsA0.917
Rv0120cfusA20.917
Rv2448cvalS0.917
Rv0120cfusA20.917
Rv2921cftsY0.909
Rv2921cftsY0.909
Rv0733adk0.903
Rv2883cpyrH0.902
Rv1649pheS0.901
Rv1649pheS0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
nocathiacin IPubChem0.8181437.54
magnesiumPubChem0.824.305
zincPubChem0.78965.409
cadmiumPubChem0.788232.515
chloridePubChem0.78835.453
glycerolPubChem0.72392.0938
MeHgPubChem0.712215.625
formatePubChem0.71245.0174
selenomethioninePubChem0.712196.106
SeMetPubChem0.712196.106
ammoniaPubChem0.71217.0305
iodidePubChem0.709127.912
nitratePubChem0.70962.0049
Nsc45514PubChem0.709177.264
polyethylene glycolPubChem0.70962.0678
NSC-45514PubChem0.709177.264
sinefunginPubChem0.709381.387
ethylene glycol; hydronPubChem0.70963.0758
S-adenosyl-L-methioninePubChem0.709399.445
S-adenosylhomocysteinePubChem0.709384.411
nchembio.341-comp1PubChem0.7081664.89
bryamycinPubChem0.7081664.89
[3,4-dihydroxy-5-(2-methylamino-6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxyphosphonic AcidPubChem0.706377.247
thiazolePubChem0.70185.1276