Rv1493

Tuberculist information
Gene namemutB
Protein functionProbable methylmalonyl-CoA mutase large subunit MutB (MCM)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1684.01
Molecular mass(da)80604.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 750
	  		  	1    MTTKTPVIGSFAGVPLHSERAAQSPTEAAVHTHVAAAAAAHGYTPEQLVWHTPEGIDVTP   60
			  	61   VYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTIRQYAGFSTAADSNAFYRR  120
			  	121  NLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDGIDLSTVSVS  180
			  	181  MTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDI  240
			  	241  FAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIRAGLNAGLDIDSFAPRL  300
			  	301  SFFWGIGMNFFMEVAKLRAGRLLWSELVAQFAPKSAKSLSLRTHSQTSGWSLTAQDVFNN  360
			  	361  VARTCIEAMAATQGHTQSLHTNALDEALALPTDFSARIARNTQLVLQQESGTTRPIDPWG  420
			  	421  GSYYVEWLTHRLARRARAHIAEVAEHGGMAQAISDGIPKLRIEEAAARTQARIDSGQQPV  480
			  	481  VGVNKYQVPEDHEIEVLKVENSRVRAEQLAKLQRLRAGRDEPAVRAALAELTRAAAEQGR  540
			  	541  AGADGLGNNLLALAIDAARAQATVGEISEALEKVYGRHRAEIRTISGVYRDEVGKAPNIA  600
			  	601  AATELVEKFAEADGRRPRILIAKMGQDGHDRGQKVIATAFADIGFDVDVGSLFSTPEEVA  660
			  	661  RQAADNDVHVIGVSSLAAGHLTLVPALRDALAQVGRPDIMIVVGGVIPPGDFDELYAAGA  720
			  	721  TAIFPPGTVIADAAIDLLHRLAERLGYTLD

Known structures in the PDB
No Known structures
1 76 151 226 301 376 451 526 601 676 751 Range: 50 to 578  |  Coverage: 70% MM_CoA_mutase Range: 617 to 735  |  Coverage: 15% B12-binding Range: 8 to 745  |  Coverage: 98% 1 Range: 50 to 578  |  Coverage: 70% 1
Number of amino acids : 750
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MM_CoA_mutasePF0164250-578
B12-bindingPF02310617-735
Mtb Structural Proteome models
Model Number1
Model nameRv1493
Template1REQ    APDBCREDO
Template coverage4_726
Template Identity(%)70.8
Model coverage(%)98.3
Normalized DOPE score-0.845

Structure Models from Chopin
Model Number1
Profilec.1.19.1
Click for model details
zscore74.06
Residue begin50
Residue end578
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1493Gene nameConfidence Score
Rv1322ARv1322A0.999
Rv1496Rv14960.999
Rv1492mutA0.998
Rv0951sucC0.984
Rv0951sucC0.984
Rv0952sucD0.974
Rv0952sucD0.974
Rv1494mazE40.968
Rv1495mazF40.967
Rv2967cpca0.948
Rv2967cpca0.948
Rv2967cpca0.948
Rv2967cpca0.948
Rv2967cpca0.948
Rv2967cpca0.948
Rv0896gltA20.942
Rv3280accD50.935
Rv1240mdh0.934
Rv1240mdh0.934
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
methylmalonyl-CoAPubChem0.989867.607
adenosylcobalaminPubChem0.9891580.59
AdoCblPubChem0.9861579.58
succinyl-CoAPubChem0.984867.607
propionatePubChem0.97974.0785
propionyl-CoAPubChem0.974823.597
L-methylmalonyl-CoAPubChem0.967867.607
(2S)-methylmalonyl-CoAPubChem0.966867.607
methylmalonyl-coenzyme APubChem0.955867.607
succinyl-coenzyme APubChem0.955867.607
carbon dioxidePubChem0.94644.0095
succinatePubChem0.931118.088
methyl-malonyl-CoAPubChem0.926867.607
protiumPubChem0.9172.01576
H(+)PubChem0.9072.01588
deuteriumPubChem0.9062.01588
suc-coaPubChem0.9867.607
CHEBI:15466PubChem0.9867.607
methyl-malonyl-coenzyme APubChem0.9862.567
n-propionyl-CoAPubChem0.9823.597
Bis-TrisPubChem0.856209.24
ethylmalonyl-CoAPubChem0.846881.633
dimethylbenzimidazole nucleotidePubChem0.804358.284
methylmalonic acidPubChem0.803118.088
sulfatePubChem0.77396.0626
cob(II)alaminPubChem0.7651329.35
5'-deoxyadenosylcobalaminPubChem0.7621579.58
cobaltPubChem0.751117.866
vitamin B12PubChem0.7491354.36
hydroxocobalaminPubChem0.7341347.36
MeCblPubChem0.7331344.38
methylcobalaminPubChem0.7261344.38
5'-deoxyadenosinePubChem0.7251.242
hydron sulfatePubChem0.7196.157
polyethylene glycolPubChem0.762.0678
ethylene glycol; hydronPubChem0.763.0758
chloridePubChem0.735.453
Malonyl-coenzyme APubChem0.7853.58
malonyl-CoAPubChem0.7853.58